Biographies
version française
Maria Roberta CILIO
Date of birth : April 28th, 1963
Place of birth : Rome, Italy
Citizenship : Italian
Marital status : married with Olivier Danhaive,
neonatologist, two children
Spoken languages : Italian, French, English, Spanish

Business Address :
Division of Neurology
Bambino Gesu'
Children's  Hospital
Piazza Sant'Onofrio 4
00165 Rome, Italy
Tel: 39.06.68592261
Fax: 39.06.68592463
Personal address :
    Via Anton Giulio Barrili 46
    00152 Rome
    Tel: 39.06.5819638
    Mobile: 39.348.4964941

Undergraduate education :
July 1982:
High School Degree: Liceo Virgilio, Rome, Italy; "Magna Cum Laude"

Graduate school education :
October 1988 :
Medical degree, University of Rome "La Sapienza", Italy, "Summa Cum Laude"

Postgraduate medical training :
September 1988 - September 1993 :
Residency in Pediatric Neurology, Summa Cum Laude, University of Rome "La Sapienza", Italy
1. 1988-1989: Department of Child Neurology, University of Rome "La Sapienza".
2. 1989-1990: Department of Child Neurology, Catholic University of Louvain, Brussels.
3. 1990-1991: Developmental Neuropathology, Catholic University of Louvain, Brussels.
4. 1991-1992: Neonatal Intensive Care Unit, Pediatric Intensive Care and Transport Unit, Catholic University of Louvain, Brussels
5. 1992-1993: Epilepsy and Neurophysiology, Bambino Gesu'Children's Hospital, Rome.

Licensures :
· October 1988 : Italian National Board For Medical Licensure
· November 1989 : Belgian National Board For Medical Licensure
· November 1993 : Italian Board Certification In Child Neurology And Psychiatry
· May 1999 : Certification of the American Board of Electroencephalography and Neurophysiology with special competence in Pediatric EEG

Awards :
· September 2000: Grant, Rita and Stanley Kaplan Family Foundation, NY, NY.
· June 2000: Grant, National Epifellow Foundation of America
· June 1999 June 2000: Fellowship, Cesare Lombroso Foundation For Epilepsy Research, Boston.
· June 1998 June 1999: Fellowship, Eugenio Litta Foundation, Geneva, Switzerland
· July 1992 May 1995: Grant #90/01/043 - Italian Ministry of Health
· December 1995 December 1997: Grant #94/01/043 - Italian Ministry of Health

Medical appointments :
· August 2001 to present: Attending Physician, Division of Neurology, Bambino Gesu' Children's Hospital, Rome.
· June 1998 July 2001:Research Fellow in Epilepsy and Clinical Neurophysiology, Department of Neurology, Children's Hospital, Harvard Medical School, Boston.
· January 1998-May 1998: Attending Physician, Division of Neurology, Bambino Gesu' Children's Hospital, Rome, Italy.
· September 1994 December 1997: Clinical Fellow in Pediatric Neurophysiology and Epilepsy, Division of Neurology, Bambino Gesu' Children's Hospital, Rome, Italy.

Main clinical activities :
  • Child Neurology Inpatients and Outpatients
  • Children with medically refractory epilepsy
  • In charge of new antiepileptic drugs trials
  • Neurologist Consultant for the Neonatal Intensive Care Unit and Pediatric Intensive Care Unit, Cardiac Surgery and Heart Transplant Unit and Hepatology Unit (neurological evaluation pre- and post-surgery).
  • EEG reports and Video-EEG reports.

Research interests :
  • Focal cortical dysplasia
  • New antiepileptic drugs
  • Neonatal seizures
  • Neurological complication pre- and post-transplant in children affected by acute and chronic liver failure.
  • Coma and brain death in children and newborns.

International publications :
1. Cilio M.R., Danhaive O., Gadisseux J.F., Otte J.B., Sokal E.M. Unusual Cyclosporine related neurological complications in liver transplant recipients. Archives of Disease in Childhood, 1993; 68: 405-407.
2. Soriani S., Scarpa P., Voghenzi A., De Carlo L., Cilio M.R. Moyamoya disease in childhood: a familial case report. Child's Nervous System 1993; 9: 215-219.
3. Curatolo P. Cilio M.R. Del Giudice E., Romano A., Gaggero R., Pessagno A. Familial white matter hypoplasia, agenesis of the corpus callosum, mental retardation and growth deficency: A new distinctive syndrome. Neuropediatrics 1993; 24: 77-82
4. Taylor T.D., Litt M., Kramer P., Pandolfo M., Angelini L., Nardocci N., Davis S., Pineda M., Hattori H., Flett J., Cilio M.R., Bertini E., Hayflick S.J. Homozygosity mapping of Hallervorden-Spatz syndrome to chromosome 20p 12.3-p13. Nature Genetics 1996, 14: 479-481.
5. Vigevano F., Cilio M.R. Vigabatrin versus ACTH as first-line treatment for Infantile Spasms: A randomized, prospective study. Epilepsia, 1997; 38: 1270-1274.
6. Bertini E., Sabatelli M., Di Capua M., Cilio M.R., Mignogna T., Federico A., Tonali P. Familial spastic paraplegia, axonal sensory-motor polyneuropathy and bulbar amyotrophy with facial dysmorphia: new cases of Troyer-like syndrome. European Journal of Paediatric Neurology 1998; 2: 245-254.
7. Leuzzi V., Lyon G., Cilio M.R., Pedespan J.M., Fontan D., Chateil J.F., Vital A. Childhood demielinating diseases with a prolonged remitting course and their relation to Schilder's disease:report of two cases. Journal of Neurology, Neurosurgery and Psychiatry 1999; 66: 407-408.
8. Huang L.T., Cilio M.R., Silveira D.C., McCabe B.K., Sogawa Y., Stafstrom C.E., Holmes G.L. Long-term effects  of neonatal seizures: a behavioral, electrophysiological and histological study. Developmental Brain Research 1999; 118: 99-107.
9. Cilio M.R., Bolanos A.R., Liu Z., Schmid, R., Yang Y., Stafstrom C.E., Mikati M.A., Holmes G. L. Anticonvulsant action and long-term effects of gabapentin in the immature brain. Neuropharmacology 2001; 40: 139-147.
10. McCabe B.K., Silveira D.C., Cilio M.R., Cha B.H., Liu X., Holmes G.L. Reduced neurogenesis following neonatal seizures. Journal of Neuroscience, 2001; 21: 2094-2103.
11. Su S.W., Cilio M.R., Sogawa Y., Silveira D.C., Holmes G.L., Stafstrom C.E. Timing of ketogenic diet initiation in an experimental model of epilepsy. Developmental Brain Research 2000; 125: 131-138.
12. Cilio M.R., Kartashov A.I., Vigevano F. The long-term use of felbamate in children with severe refractory epilepsy. Epilepsy Research 2001; 47: 1-7.
13. Zhou B., Bae S.K., Malone A.C., Levinson B.B., Kuo Y., Cilio M.R., Bertini E., Hayflick S.J., Gitschier J.M. hGFRalpha-4: a new member of the GNDF receptor family and a candidate for NBIA. Pediatric Neurology 2001;25: 156-161.

National publications :
1. Gressens P., Cilio M.R., Schlogel X. Evrard Ph. Les mécanismes de la souffrance cérébrale du fetus et du prématuré. Progrès en Néonatologie, Vol.11, 1991. Ed. Scient. Prof. J.P. Relier. Ed. Karger.
2. Fusco L., Cilio M.R., Vigevano F. Le crisi di spasmo oltre la sindrome di West. Bollettino Lega Italiana Contro l'Epilessia 1993; 84: 191-192.
3. Ricci S., Cilio M.R., Di Capua M., Realacci M.G., Vigevano F. Lo stato epilettico come complicanza di intervento cardiochirurgico in età pediatrica. Bollettino Lega Italiana Contro l'Epilessia 1993; 84: 117-118.
4. Vigevano F., Cilio M.R., Dalla Bernardina B. Manifestations paroxystiques non épileptiques de la première année de vie. In: Les Epilepsie de l'enfant. Ed. Labaz, 1993; 79-81.
5. Cilio M.R. L'EEG nel coma del bambino. In: Argomenti di EEGrafia clinica. Medical Communication Ed. 1997.

Invited lectures :
6. Cilio M.R. Il coma e la morte cerebrale nel bambino. 8° Corso avanzato di Elettroencefalografia  Clinica. Gargnano, 5-12-Marzo 1995.
7. Cilio M.R. L'EEG nel coma del bambino. 9° Corso di Aggiornamento in Elettroencefalografia Clinica. Gargnano, 4-12 Marzo 1996
8. Cilio M.R., Sabatelli M. Hereditary Sensory and Autonomic Neuropathies: Clinical and neuropathological study. Seminar on Hereditary Sensory and Autonomic Neuropathies, Roma, 6 Novembre 1996.
9. Cilio M.R. Fisiopatologia del danno cerebrale di origine anossico-ischemica perinatale. Seminario sulla Sofferenza Perinatale e Deficit di GH. Roma, 6 Dicembre 1996.
10. Cilio M.R. L'EEG patologico nel neonato. 10° Corso di Aggiornamento di  Elettroencefalografia Clinica. Gargnano, 3-11 Marzo 1997.
11. Cilio M.R. Terapia dell'epilessia della prima e seconda infanzia. Congresso Nazionale " Nuovi Farmaci per la Neuropsichiatria dello Sviluppo", IV Corso Monografico di Neuropsicofarmacologia. Alba (Cuneo), 26-27 Settembre 1997.
12. Cilio M.R. Manifestazioni parossistiche non epilettiche nel neonato. Corso avanzato di Epilettologia. Gargnano, 15- 22 Novembre 1998.
13. Cilio M.R. Manifestazioni parossistiche non epilettiche versus convulsioni in epoca neonatale. XII Corso di base in Elettroencefalografia Clinica. Gargnano, 1-10 Marzo 1999.
14. Cilio M.R. Convulsioni neonatali versus manifestazioni parossistiche non epilettiche. XIII Corso di    base in Elettroencefalografia Clinica. Gargnano, 5-13 Marzo 2000.


Communications  and  posters :
1. Cilio M.R., Danhaive O., Sokal E.M., Gadisseux J.F., Otte J.B. Seizures associated with toxic levels of Cyclosporine A in liver transplanted children. Pediatric Research 1991; 30: 650.
2. Cilio M.R., Danhaive O., Sokal E.M., Gadisseux J.F., Otte J.B. Intoxication à la Cyclosporine et convulsions après transplantation hépatique chez l'enfant. XIX Journées de la Societé Belge de Pédiatrie. Bruxelles, 1991
3. Bertini E., Sabatelli M., Di Capua M., Claps D., Cusmai R., Cilio M.R., Federico A., Tonali P. Hereditary spastic paraplegia, sensory-motor polyneuropathy due to axonal dystrophy and dysmorphic facial myokymia in two sibs. A new disease. Annals of Neurology 1992; 32: 442 (57).
4. Curatolo P., Arpino C., Cilio M.R., Stazi M.A., Medda E. Facteurs de risque d'épilepsie focale précoce symptomatique. Revue Neurologique 1993; 149: 239.
5. Vigevano F., Claps D., Cilio M.R., Faberi A., Gisondi A. Vigabatrin versus ACTH nel trattamento di prima scelta della sindrome di West. Epilepsie - Blatter 1993; suppl.6: 50.
6. Ricci S., Cusmai R., Fusco L., Cilio M.R., Vigevano F. Reflex myoclonic  epilepsy of the first year of life. Epilepsia 1993; suppl.6: 47.
7. Leuzzi V., Cilio M.R., Pedespan J.M., Fontan D., Chateil J.F., Vital A., Lyon G. Schilder myelinoclastic diffuse sclerosis. Pediatric Neurology 1994; 11: 166.
8. Vigevano F., Claps D., Cilio M.R., Faberi A., Gisondi A. Vigabatrin versus ACTH come terapia di prima scelta nella sindrome di West. Bollettino Lega Italiana Contro l'Epilessia 1994; 86/87: 113-114.
9. Ricci S., Vigevano F., Fusco L., Cilio M.R., Cusmai R. Startle Benign Myoclonic Epilepsy in Infancy. Epilepsia 1994, Suppl. 7; 87.
10. Vigevano F., Cilio M.R., Fusco L., Pirozzi N. Le coma chez l'enfant. Présentation d'une nouvelle échelle d'évaluation. Atti della "22ème Réunion fermée" Societé Européenne de Neurologie Pédiatrique. 1994.
11. Cilio M.R., Fusco L., Villani A., Vigevano F. Détérmination de la mort cérébrale chez l'enfant et le nouveau-nè. Atti della "22ème Réunion fermée" Societé Européenne de Neurologie Pédiatrique.1994.
12. Cilio M.R., Bonardi R., Vigevano F. Complete remission of myoclonic-astatic seizures in a child with Felbamate add-on therapy. Developmental Medicine and Child Neurology 1995;37 (3): 22.
13. Vigevano F., Cilio M.R., Claps D., Faberi A., Gisondi A. Vigabatrin versus ACTH as first-line therapy in West syndrome. Developmental Medicine and Child Neurology  1995; 37 (3): 22.
14. Ricci S., Cilio M.R., Di Capua M., Realacci M.G., Squitieri C., Vigevano F. Status epilepticus EEG monitoring after cardiac surgery in children. Electroencephalography and Clinical Neurophysiology 1995; 94: 25P.
15. Vigevano F., Cilio M.R., Faberi A., Gisondi A., Cusmai R. Vigabatrin versus ACTH in the treatment of infantile spasms. Epilepsia 1995; 36: S265.
16. Cilio M.R., Fariello G., Romeo A., Vigevano F. Straight Frontal Horn as the only neuroradiological feature of epileptogenic lesion. Epilepsia 1996; 37:38.
17. Cilio M.R., Bonardi R., Vigevano F. The efficacy of felbamate as add-on therapy in children and adolescents with refractory epilepsy.  Epilepsia 1997; 38 Suppl.3: 74.
18. Cilio M.R., Vigevano F. Felbamate add-on in refractory epilepsy: an open-label study with long term follow-up. Annals of Neurology 1997; 42: 506.
19. Cilio M.R., Bertini E., Sabatelli M., De Armas L., Axelrod F. Congenital Panneuropathy with central nervous system involvement. Annals of Neurology 1997; 42: 531.
20. Cilio M.R., Pachaz C., Vigevano F. Vigabatrin versus ACTH comme traitement de première choix dans les spasmes infantiles: une étude prospective randomisée. Actes du 6ème Congrès de la Société Européenne de Neurologie Pédiatrique,  Rome, 1997.
21. Cilio M.R., De Volder A.G., Di Capua M., Fariello G. Bertini E. Tomographie à Emission de Positrons dans le diagnostic précoce de la maladie de Hallervorden-Spatz. Actes du 6ème Congrès de la Société Européenne de Neurologie Pédiatrique, Rome, 1997.
22. Di Capua M., Cilio M.R., Fariello G., Longo D., Digilio M.C., Dionisi Vici, Bertini E. Hypoplasie ponto-cérébelleuse familiale de type 2: description de deux cas. Actes du 6ème Congrès de la Société Européenne de Neurologie Pédiatrique, Rome, 1997.
23. Sebastianelli R., Cilio M.R., Fusco L., Vigevano F. Nocturnal frontal lobe epilepsy: a family with constant phenotype and high penetrance. European Journal of Paediatric Neurology 1997; 1: A45.
24. Fusco L., Cilio M.R., Di Capua M., Vigevano F. Congenital ceroidolipofuscinoses:spectrum of seizures. Epilepsia 1998:39:S150.
25. Cilio M.R., Huang L-T, Silveira D.C., Soman T.B., Holmes G.L. Age-dependant hippocampal damage following lithium-pilocarpine status epilepticus in rats. Neurology 1999; 52: A38.
26. Silveira D.C., Cilio M.R., Huang L-T, McCabe B.K., Stafstrom C.E. Fos expression in the locus coeruleus after kainic acid-induced seizures in immature rats. Neurology 1999; 52: A50.
Liu X., Cilio M.R. , Silveira D.C., Holmes G.L. Application of place cell recording method to investigate the functional changes of hippocampal pyramidal cells in rats with status epilepticus. Epilepsia 2000; 40 Suppl. 7: 44.

©2001 Ph. Evrard