Biographies
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Robert Arthur OUVRIER
NAME: ROBERT ARTHUR OUVRIER
DOB: 17th May, 1940
NATIONALITY: Australian
MARITAL STATUS: Married
Number of Children: Three
QUALIFICATIONS:
1956 - Leaving Certificate-- Honours in Latin and French
1961 - B. Sc(Med). (Hons)-- Physiology. University of Sydney
1964 - M.B., B.S. (Hons) University of Sydney
(9th in class of 220)
1967 - M.R.A.C.P.
1972 - F.R.A.C.P.
1986 - M.D.
University of Sydney
SCHOLARSHIPS
Undergraduate: Gillies Prize for Pathology
University of Sydney.
Postgraduate: Nestlé Paediatric Travelling Scholarship, 1968
Postgraduate Medical Scholarship, University of Sydney, 1969.
AWARDS
Chevalier de l'Ordre National du Mérite, Republic of France, 1996.
POSITIONS HELD:
1964 Junior Resident Medical Officer Royal Prince Alfred Hospital, Sydney
1965 Junior Resident Medical Officer
Royal Alexandra Hospital for Children, Sydney.
1966 Medical Registrar, Princess Margaret Hospital, Perth.
1967 Medical Registrar, Professorial Unit,
Royal Alexandra Hospital for Children, Sydney.
1968 Medical Registrar, Royal Children's Hospital, Melbourne
{incl. 6 months rotation (Registrar then Consultant Paediatrician) New Guinea}.
1969 Honorary Physician and Fellow in Neurology,
Royal Children's Hospital, Melbourne
1969/71 Fellow in Neurology, University of Kentucky, U.S.A.
1971/72 Fellow in Neurology,
John Hopkins University, Baltimore, U.S.A.
1972 Staff Physician in Neurology,
Royal Alexandra Hospital for Children, Sydney.
1978- present Head, T Y Nelson Department of Neurology and Neurosurgery,
Royal Alexandra Hospital for Children, Sydney.
ADDITIONAL APPOINTMENTS:
1972 Honorary Associate Physician,
Royal Prince Alfred Hospital, Sydney
1973 Clinical Lecturer, Paediatrics
University of Sydney.
1977 Visiting Consultant in Paediatric Neurosciences,
Royal Newcastle Hospital, NSW
1980 Visiting Consultant in Paediatric Neurology,
The Women's Hospital, Crown Street, Sydney.
1984 Consultant Paediatrician,
Sydney Eye Hospital.
1984 Visiting Medical Officer, Paediatric Neurology,
Westmead Hospital, Sydney
1992 Clinical Associate Professor, Dept. of Paediatrics,
University of Sydney.
1996-7 Invited Professor, University of Paris VII, Hopital Robert Debré.
1997 Honorary Consultant Neurologist, Sydney Children's Hospital, Randwick, NSW
1997 Consultant Neurologist, Royal North Shore Hospital, St. Leonards, Sydney
1999 Clinical Professor, Dept. of Paediatrics,
University of Sydney.
RESEARCH GRANTS:
1975-1979 Royal Alexandra Hospital for Children
"Studies on Phenobarbitone Metabolism in the Neonate".
1979-81 Children's Medical Research Foundation Grant-in-Aid
"A study of Chronic Peripheral Neuropathy in Childhood".
(with Professor J G McLeod).University of Sydney.
1981-82 National Health and Medical Research Council
"Chronic Peripheral Neuropathy in Childhood".
(with Professor J G McLeod).
1990 Peripheral Nerve Foundation, University of Sydney.
"Schwann cell Responsiveness and Biology in Inherited Neuropathies"
(with Dr P. Armati)
1991 Government Employees Assistance to Medical Research Fund
"Schwann cell characteristics of inherited childhood neuropathies".
(with Dr. P. Armati)
1994-1997 Children's Hospital Fund.
"A screening test of higher mental function in normal and impaired children"
(with J E Hendy, L Bornholt, F Black).
1998 National Health and Medical Research Council
" SYSTEMS: A screening test of higher mental function in childhood"
(with J E Hendy, L Bornholt, F Black).
SPECIAL SOCIETIES ETC:
1. Royal Australasian College of Physicians - 1967.
Member Specialist Advisory Committee in Neurology - 1976-82,
1984-86.
Member, Written Examinations Committee, Paediatrics - 1989-1996
2. Australian Association of Neurologists - 1972.
Member General Advisory Committee - 1992.
3. Australian College of Pediatrics
4. International Child Neurology Association.
Vice-President - 1975-79.
Chairman, Executive Committee, Second International Child
Neurology Congress, Sydney - 1979.
Councillor - 1986-1990.
Convenor, International Training Committee- 1993
Member, Steering Panel, International Training and Education Committtee-1997-5. Asian Oceanian Child Neurology Association
Australian Delegate - 1983- present.
Vice-President 1987-1994.
Member Steering Committee,
2nd Asian Oceanian Child Neurology Congress - 1986.
Member, Scientific Programme Committee AOCCN- 1990 and 1994.
6. Member Editorial Board,
Brain and Development, Tokyo.
7. Member Editorial Board,
Journal of Child Neurology, Littleton, Massachusetts, U.S.A.
8. Association Medicale Francophone d'Australie.
President - 1992-93.
INVITED OVERSEAS LECTURESHIPS:
International Symposium on Developmental Disabilities, Tokyo, 1977.
Master of Medicine Course, (Paediatrics), University of Singapore, 1977.
University of Indonesia, Jakarta, 1981.
International Symposium on Developmental Disabilities, Tokyo, 1981.
First Asian Oceanian Congress of Child Neurology, Taiwan, 1983.
Heritage Visiting Lectureship, University of Calgary, Canada, 1983.
Second International Conference on Charcot-Marie-Tooth Disease,
New York, 1987.
Sri Lankan Paediatric Association, Colombo, 1989.
International Paediatric Congress, Paris, 1989.
Airen Conference on Peripheral Neuropathy in Childhood, Geneva, 1989.
New Zealand Paediatric Association, 1989.
5th International Child Neurology Congress. Tokyo, 1990.
Plenary Lecturer, Joint Congress of the International Child Neurology
Association and Asian Oceanian Child Neurology Association, Tokyo, 1990.
Visiting Professor, Sheffield Children's Hospital, 1992.
New Zealand Paediatric Association, 1992.
AIDAB Lecturer, University Sains Malaysia, 1993.
Korean Child Neurology Association, 1994.
International Symposium (Fukuyama Festschrift), Tokyo, 1994.
Plenary Lecturer, Joint Congress of the International Child Neurology Association and the American Child Neurology Association, San Francisco, 1994.
Asian-Oceanian Child Neurology Association, Chieng Mai, 1994.
Carrell-Krusen Lecturer, Dallas, USA, 1995.
Choongqing University, China, 1996.
Asian- Oceanian Child Neurology Association, Istanbul, 1996.
Invited Professor, The University of Paris VII, 1996-1997.
International Symposium on Child Neurology, San Servolo, Venice, 1997.
Child Neurology Society of the Philippines, 1997.
Symposium on Neuromuscular Disorders, New Caledonia, 1998
Free University of Brussells 1999
ICNA Lecturer, Montevideo, 1999.
Lecturer and External Examiner, University of Malaysia, Kuala Lumpur, 1999
CURRENT AND PREVIOUS RESEARCH:
1. A major project has been a long-term and ongoing study
of chronic peripheral neuropathy in childhood. A thesis for the degree
of Doctor of Medicine in the University of Sydney was accepted in
1986. A textbook was published in 1990 (with J G McLeod and
J G Pollard). The Second Edition is with the publishers.
2. A second major area of current interest is the development
and validation of a screening test of higher mental function in
childhood (with J.Hendy, L.Bornholt and F. Black).
3. A study of CSF amino-acid and neurotransmitters in epilepsy
(with R. Goldsmith). Completed.
4. Various studies on anticonvulsant measurement and utilization in
childhood. Completed. Six papers published.PUBLICATIONS
BOOKS:
Ouvrier RA (Ed). Controversies in Childhood Epilepsy.
Excerpta Medica Sydney, 1986.
Ouvrier RA, McLeod JG, Pollard JD.
Peripheral Neuropathy in Childhood, Raven New York, 1990.
(Review: Iannaccone ST. J Child Neurol 1992; 7: 322-323).
Ouvrier RA, McLeod JG, Pollard JD.
Peripheral Neuropathy in Childhood, Second Edition, MacKeith Press, London 1999.
SCIENTIFIC ARTICLES:
Ouvrier RA, Hopkins IJ. "Occlusive disease of the vertebrobasilar arterial system in childhood".
Devel Med Child Neurol 1970; 12:186-192.
Ouvrier RA, Prineas J, Walsh JC, Reye RDK, McLeod JG."Giant axonal neuropathy - a third case". Proc Aust Assoc Neurol 1974;11:137..
Wise GA, Ouvrier R. "The Aicardi syndrome". Proc Aust Assoc Neurol 1974; 11: 103-113.
Ouvrier RA. "Plasma diphenylhydantoin Levels". Aust. N.Z.J. Med 1974; 4:524-525.
Ouvrier RA "CSF imaging in paediatrics. Med J Aust 1974; 2: 146-147.
McCaughan B, Ouvrier RA, de Silva M, McLaughlin AF. "The value of the brain scan and cerebral arteriogram in the Sturge-Weber syndrome". Proc Aust Assoc Neurol 1975; 12:185-190.
Prineas JW, Ouvrier RA, Wright RG, Walsh J C, McLeod JG. "Giant axonal neuropathy - a generalised disorder of cytoplasmic microfilament formation".
J Neuropath Exp Neurol 1976; 35: 459-470.
Ouvrier RA, Goldsmith R. "Phenobarbitone dosage in the neonate - preliminary communication".
Proc Aust Assoc Neurol 1977; 14:194-202.
Ouvrier RA. "Pertussis immunization - a neurologist's viewpoint". Med J Aust 1978; 2: 300-301.
*Ouvrier RA. Progressive dystonia with marked diurnal fluctuation". Ann Neurol 1978; 4: 412-417.
Ouvrier RA "The West and Lennox Syndromes" Asian Med J 1978; 21:516-523.
Hoyt CS, Billson F, Ouvrier RA, Wise GA. "Ocular features of Aicardi's syndrome".
Arch Ophthalmol 1978; 96:291-295.
Anthony JH, Procopis P, Ouvrier RA. "Benign acute childhood myositis". Neurology 1979; 29:1068-1071.
Procopis PG, Ouvrier RA. "Adrenoleukodystrophy: a study of four patients".
Clin Exp Neurol 1979;16:133.
Antony JH, Ouvrier RA, Wise GA. "Spasmus nutans: a mistaken entity". Arch Neurol 1980; 37: 373-375.
Murell WG, Ouvrier RA, Stewart BJ, Dorman DC. "Infantile botulism in a breast-fed infant from rural N.S.W". Med J Aust 1981;1:583.
Lewis D, Ouvrier RA, Procopis PG et al. "Bilateral optic nerve hypoplasia" Aust Paed J 1981; 17:48 (Abstract).
*Ouvrier RA, McLeod JG, Morgan GJ, Wise GA, Conchin TE. "Hereditary motor and sensory neuropathy of neuronal type with onset in early childhood". J Neurol Sci 1981; 51:181-197.
Goldsmith R, Ouvrier RA. "Salivary anticonvulsant levels in children: a comparison of methods".
Ther Drug Monitoring 1981; 3: 151-157.
Ouvrier RA, Lewis E, Procopis PG, Billson FA, Silink M, de Silva M. "Bilateral optic nerve hypoplasia". Clin Exp Neurol 18:52, 1981.
Procopis PG, Ouvrier RA. Sodium valproate: a five-year follow-up. Aust Paed J 1981; 5:85-94 (Abstract).
Paisley WJ, Ouvrier RA, Johnston I, Jones RFA, Sofer-Schreiber J, de Silva M. "Chronic spinal arachnoiditis in childhood". Devel Med Child Neurol 1982; 24: 798-804.
Ouvrier RA, Goldsmith R."The pharmacokinetics of phenobarbitone and phenytoin in the neonate".
In: Child Neurology. Proceedings of the TYDP International Symposium on Developmental Disabilities. ed. Fukuyama Y et al. Excerpta Medica, Amsterdam, 1982 pp 282-289.
Goldsmith R, Ouvrier RA, Procopis PG. Diurnal variation in anticonvulsant levels Aust Paed J 1982; 18:140-141 (Abstract).
*Ouvrier RA, Goldsmith RF. Phenobarbitone dosage in neonatal convulsions. Arch Dis Child 57:653-657, 1982.
*Ouvrier RA, McLeod JG, Conchin T. "Friedreich's ataxia: early detection and progression of peripheral nerve abnormalities". J Neurol Sci 1982; 55:137-145.
Ouvrier, R.A. "Some benign paroxysmal disorders of childhood". Aust Fam Physician 1983; 12: 389-392.
Sutton DL, Ouvrier RA. "Cerebral abscess in the under 6 month age group. Arch Dis Child 1983; 58: 901-905.
Ouvrier RA " Advances in neonatal neurology". Brain Dev 1984; 6: 520-527.
Sutton L, Ouvrier RA. "Headache in childhood" Aust Fam Physician 1985; 14:777-780.
Ouvrier RA "Chronic peripheral neuropathy". M.D. Thesis. University of Sydney, 1985.
Ouvrier RA, Billson FA. "Optic nerve hypoplasia: a review". J Child Neurol 1986; 1:181-8.
Ouvrier RA, McLeod JG, Conchin T. "Morphometric studies of sural nerve in childhood". Muscle Nerve 1986; 10:47-53.
Ouvrier, R.A. "Petit mal". In: Ouvrier, R.A. (Ed) Controversies in Childhood Epilepsy.
Excerpta Medica Sydney, 1986.
Cunningham A, Griffith N, Goldsmith R, Procopis P, Ouvrier RA, Bandler T. "Alterations in cerebrospinal fluid GABA in an experimental model of epilepsy" Aust Paed J 1986. (Abstract).
*Ouvrier RA, McLeod JG, Conchin TE. "The hypertrophic forms of hereditary motor and sensory neuropathy. A study of hypertrophic Charcot-Marie-Tooth disease (HMSN type I) and Dejerine-Sottas disease (HMSN type III) in childhood". Brain 1987; 110:121-148.
McElligot I, Ouvrier RA, Procopis PG. "Eyelid myoclonia". Aust NZ J Med 1988; 18:469 (Abstract)
Collins FA, Constantinou JE, Ouvrier RA, Procopis PG. Acute infectious polyneuropathy in children: a follow-up study. Aust J Paed 1988. 24: 66-67 (Abstract).
*Ouvrier RA, Billson F. "Benign paroxysmal tonic upgaze of childhood". J Child Neurol 1988; 3: 177-180.
Ouvrier RA, McLeod JG "Chronic peripheral neuropathy in childhood - an overview".
Aust Paed J Suppl. 1988; 24: 80-82.
De Jong APM, Haan EA, Manson JI, Wise GA, Ouvrier RA, Wadman SK. "Kinetic study of catecholamine metabolism in hereditary progressive dystonia". Neuropaediatrics 1989; 20: 3-11.
Constantinou J, Gillis J, Ouvrier RA, Rahilly PM. "Hypoxic- ischaemic encephalopathy after near miss sudden infant death syndrome". Arch Dis Child 1989; 64:703-708.
Ouvrier RA. "Giant axonal neuropathy - a review". Brain Dev 1989; 11:207-14.
North K, Ouvrier RA, Nugent M. "Pseudoseizures caused by hyperventilation resembling absence epilepsy". J Child Neurol 1990. 5: 288-94.
Macdonald WB, Tink AR, Ouvrier RA, Menser MA, de Silva LM, Naim H, Hawkes RA. "Japanese encephalitis after a two-week holiday in Bali" Med J Aust 1989; 150: 334-336.
Ouvrier RA. "Pallor of the optic disc in childhood". Aust NZ J Ophthalmol 1990;18: 375-379.
Ouvrier, R.A. "The hereditary peripheral neuropathies in childhood".
New Issues in Neurosciences 1990; 2:43-59.
Dhiravibulya K, Ouvrier RA, Johnston I H, Procopis P, Antony J. "Benign intracranial hypertension in childhood: a review of 23 patients". J. Paediatr. Child Health 1991; 27: 304-7.
Dewez P, North K, de Silva M, Ouvrier R, Isaacs D. " Fever and spastic quadriparesis caused by Mycoplasma pneumoniae". Ped Inf Dis J 1992; 11: 129-130.
Charuvanij A, Ouvrier RA, Procopis PG, Antony JH, Fagan ER. " ACTH treatment in intractable seizures of childhood". Brain Devel 1992: 14: 102-106.
Reutens D, Bye A, Hopkins I, Danks A, Somerville E, Walsh J, Bleasel A, Ouvrier R, McKenzie R, Manson J, Bladin P, Berkovic S. "Corpus callosotomy for intractable epilepsy: seizure outcome and prognostic factors". Epilepsia 1993; 34: 904-909.
North KN, Ouvrier RA, McLean CA, Hopkins IJ. "Idiopathic hypothalamic dysfunction with dilated unresponsive pupils". J Child Neurol 1994; 9: 320-325.
North K, Kan A, de Silva M, Ouvrier R. "Hemiplegia due to posterior cerebral artery occlusion".
Stroke 1993; 24: 1757-1760.
Kozlowski K, Ouvrier RA. "Agenesis of the corpus callosum with mental retardation and osseous lesions. Am J. Med. Genet 1993; 48: 6-9.
*Ouvrier RA, Goldsmith RF, Ouvrier S, Williams IC. "The Value of the Mini-Mental State Examination in childhood: a preliminary study". J. Child Neurol 1993; 8:145-8
Ouvrier, R.A. "Henri Parinaud and his syndrome". Med J Aust 1993; 158:711-3
Hayasaka K, Himoro M, Sawaishi Y, Nanao K, Takahashi T, Takada G, Nicholson G.A., Ouvrier, R.A., Tachi N. "De novo mutation of the myelin Po gene in Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III)" Nature Genetics 1993; 5: 266-268.
Ouvrier RA, Nicholson GA. "Advances in the genetics of hereditary hypertrophic neuropathy in childhood". Brain Devel 1995; suppl 17: 31-37.
*Ouvrier R, Nunn K, Sprague T, McLean C, Arbuckle S, Hopkins I, North K."Idiopathic hypothalamic dysfunction: a paraneoplastic syndrome" Lancet 1995; 346: 1298 (Letter)
Valentijn LJ, Ouvrier RA, van den Bosch NH, Bolhuis PA, Baas F, Nicholson GA. "Dejerine-Sottas neuropathy is associated with a de novo PMP22 mutation". Hum Mutation. 1995; 5: 76-80.
*Ouvrier R "Correlation between the histopathologic, genotypic, and phenotypic features of hereditary peripheral neuropathies in childhood" J Child Neurol 1996; 11: 133-146.
Ouvrier RA "Hereditary neuropathies in children: the contribution of the new genetics". Sem Ped Neurol 1996; 3: 140-151.
O'Meara M, Ouvrier R. "Viral encephalitis in children". Curr Opin Ped 1996; 8: 11-15.
Grattan-Smith PJ, Morris JG, Johnston HM, Yiannikas C, Malik R, Russell R, Ouvrier RA "Clinical and neurophysiological features of tick paralysis". Brain 1997;120: 1975-1987.
Ikegami T, Nicholson G, Ikeda H, Ishida A, Johnston H, Wise G, Ouvrier R, Hayasaka K. "A novel homozygous mutation of the myelin Po gene producing Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III)". Biochem Biophys Res Commun 1996; 222: 107-110
Manomani V, Ouvrier RA. "Intravenous immunoglobulin treatment in childhood Guillain-Barré Syndrome". Dev Med Child Neurol 1997; 39: 425(Letter).
Murofushi T, Ouvrier RA, Parker GD, Graham RI, da Silva M, Halmagyi GM. "Vestibular abnormalities in CHARGE association". Ann Otol Rhinol Laryngol 1997;106: 129-134.
Nunn K, Ouvrier R, Sprague T, Arbuckle S, Docker M."Idiopathic hypothalamic dysfunction: a paraneoplastic syndrome?" J Child Neurol 1997; 12: 276-281.
Howe AM, Lipson AH, de Silva M, Ouvrier R, Webster WS. "Severe cervical dysplasia and nasal cartilage calcification following prenatal warfarin exposure". Am J Med Genet 1997; 71: 391-396.
Sander S, Ouvrier RA, Nicholson G, Pollard JD McLeod JG. "The clinical and
histopathological features of MPZ and PMP22 mutations". Proceedings of the Peripheral Nerve Society Cambridge 1997. (Abstract).
Hayes M, Ouvrier RA, Evans W, Somerville E, Morris JGL. X-linked dystonia-deafness syndrome. Movement Disorders 1998; 13: 303-308.
Ikegami T, Nicholson G, Ouvrier R, et al.(1998) De novo mutation of the myelin Po gene in Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III): two amino acid insertion after Asp 118. Human Mutation: Suppl.1: S103-105 .
Ng Y, Wu T, Ouvrier RA. "Drug therapy in juvenile dermatomyositis. A follow-up study". J Child Neurol 1998; 13: 109-112.
Ouvrier RA Progrès en génétique des neuropathies périphériques chez l'enfant. Arch Pédiatr 1998; 5: 480-483.
Ouvrier RA The hypomyelinating neuropathies of mice and men. Rev Neurol (Paris) 1998; 154: 481-487.
Ouvrier RA "Update on acute and chronic inflammatory polyneuropathy" J Child Neurology 1999; 4: 53-57.
BOOK CHAPTERS:
Ouvrier RA, Freeman JM, McKhann G. "The value of cerebrospinal fluid imaging in paediatrics" in Paediatric Nuclear Medicine. Ed. A.E. James, W.B. Saunders, Philadelphia, 1974.
Ouvrier RA, North K, Nugent M, Vignaendra V. "Pseudoseizures resembling petit mal caused by hyperventilation". Grey Areas in Epilepsy. Ed. F. Vajda & G. Donnan, York. Melbourne, 1985.
Ouvrier RA. "Migraine versus epilepsy". In: Epilepsy, A Symposium. Ed. N. A Symposium. Sydney. 1988;7-9.
Goldsmith RF, Earl JW, Ouvrier RA, Procopis P, Cunningham A. "CSF amino acids in childhood epilepsy" In: Amino Acids, Chemistry, Biology and Medicine. Ed Lubec G, Rosenthal G.A. Escom Leiden 1990; pp 415-21.
Ouvrier RA. "Cerebral Palsy" In: A Textbook of Paediatrics. 2nd Edition.
Ed. by M. Robinson, Churchill Livingstone, Melbourne, 1990.
Ouvrier RA, McLeod JG. "Hereditary motor and sensory neuropathy type 111". In: Charcot-Marie-Tooth Disorders - Pathophysiology, Molecular Genetics and Therapy. Ed. R.E. Lovelace and H.K. Shapiro. Wiley Liss, New York, 1990.
Ouvrier RA, McLeod JG. "Hereditary sensory neuropathy. In: J.M.B.V. De Jong ed. Handbook of Clinical Neurology. Vol.60: Elsevier. Amsterdam 1991, pp 5-22.
Ouvrier RA. "Peripheral neuropathies in childhood" In: Fetal and Perinatal Neurology. Eds: Y.Fukuyama, Y.Suzuki, S.Kamoshita, P.Casaer. Karger Basel, 1992 pp 60-78.
WORK IN PRESS
Ouvrier RA and Collins K Cerebral palsy and degenerative diseases. In : Robertson M and Roberton D Eds. Practical Paediatrics. 1999 In press.
Smith S Ouvrier RA. Peripheral Neuropathy in: Swaiman K (Ed.) Pediatric Neurology 1999. In press.
WORK COMPLETED
Sander S Nicholson GA Ouvrier RA McLeod JG Pollard JD."Charcot-Marie-Tooth disease: histopathological features of the peripheral myelin protein (PMP22) duplication (CMT1A) and Connexin mutations (CMTX1)". Muscle Nerve 1998. Manuscript accepted.
*Ouvrier R, Hendy J, Bornholt L, Black F. "The development of SYSTEMS: Sydney Screening Test for the Evaluation of Mental Status". J Child Neurol In press 1999
DOB: 17th May, 1940
NATIONALITY: Australian
MARITAL STATUS: Married
Number of Children: Three
QUALIFICATIONS:
1956 - Leaving Certificate-- Honours in Latin and French
1961 - B. Sc(Med). (Hons)-- Physiology. University of Sydney
1964 - M.B., B.S. (Hons) University of Sydney
(9th in class of 220)
1967 - M.R.A.C.P.
1972 - F.R.A.C.P.
1986 - M.D.
University of Sydney
SCHOLARSHIPS
Undergraduate: Gillies Prize for Pathology
University of Sydney.
Postgraduate: Nestlé Paediatric Travelling Scholarship, 1968
Postgraduate Medical Scholarship, University of Sydney, 1969.
AWARDS
Chevalier de l'Ordre National du Mérite, Republic of France, 1996.
POSITIONS HELD:
1964 Junior Resident Medical Officer Royal Prince Alfred Hospital, Sydney
1965 Junior Resident Medical Officer
Royal Alexandra Hospital for Children, Sydney.
1966 Medical Registrar, Princess Margaret Hospital, Perth.
1967 Medical Registrar, Professorial Unit,
Royal Alexandra Hospital for Children, Sydney.
1968 Medical Registrar, Royal Children's Hospital, Melbourne
{incl. 6 months rotation (Registrar then Consultant Paediatrician) New Guinea}.
1969 Honorary Physician and Fellow in Neurology,
Royal Children's Hospital, Melbourne
1969/71 Fellow in Neurology, University of Kentucky, U.S.A.
1971/72 Fellow in Neurology,
John Hopkins University, Baltimore, U.S.A.
1972 Staff Physician in Neurology,
Royal Alexandra Hospital for Children, Sydney.
1978- present Head, T Y Nelson Department of Neurology and Neurosurgery,
Royal Alexandra Hospital for Children, Sydney.
ADDITIONAL APPOINTMENTS:
1972 Honorary Associate Physician,
Royal Prince Alfred Hospital, Sydney
1973 Clinical Lecturer, Paediatrics
University of Sydney.
1977 Visiting Consultant in Paediatric Neurosciences,
Royal Newcastle Hospital, NSW
1980 Visiting Consultant in Paediatric Neurology,
The Women's Hospital, Crown Street, Sydney.
1984 Consultant Paediatrician,
Sydney Eye Hospital.
1984 Visiting Medical Officer, Paediatric Neurology,
Westmead Hospital, Sydney
1992 Clinical Associate Professor, Dept. of Paediatrics,
University of Sydney.
1996-7 Invited Professor, University of Paris VII, Hopital Robert Debré.
1997 Honorary Consultant Neurologist, Sydney Children's Hospital, Randwick, NSW
1997 Consultant Neurologist, Royal North Shore Hospital, St. Leonards, Sydney
1999 Clinical Professor, Dept. of Paediatrics,
University of Sydney.
RESEARCH GRANTS:
1975-1979 Royal Alexandra Hospital for Children
"Studies on Phenobarbitone Metabolism in the Neonate".
1979-81 Children's Medical Research Foundation Grant-in-Aid
"A study of Chronic Peripheral Neuropathy in Childhood".
(with Professor J G McLeod).University of Sydney.
1981-82 National Health and Medical Research Council
"Chronic Peripheral Neuropathy in Childhood".
(with Professor J G McLeod).
1990 Peripheral Nerve Foundation, University of Sydney.
"Schwann cell Responsiveness and Biology in Inherited Neuropathies"
(with Dr P. Armati)
1991 Government Employees Assistance to Medical Research Fund
"Schwann cell characteristics of inherited childhood neuropathies".
(with Dr. P. Armati)
1994-1997 Children's Hospital Fund.
"A screening test of higher mental function in normal and impaired children"
(with J E Hendy, L Bornholt, F Black).
1998 National Health and Medical Research Council
" SYSTEMS: A screening test of higher mental function in childhood"
(with J E Hendy, L Bornholt, F Black).
SPECIAL SOCIETIES ETC:
1. Royal Australasian College of Physicians - 1967.
Member Specialist Advisory Committee in Neurology - 1976-82,
1984-86.
Member, Written Examinations Committee, Paediatrics - 1989-1996
2. Australian Association of Neurologists - 1972.
Member General Advisory Committee - 1992.
3. Australian College of Pediatrics
4. International Child Neurology Association.
Vice-President - 1975-79.
Chairman, Executive Committee, Second International Child
Neurology Congress, Sydney - 1979.
Councillor - 1986-1990.
Convenor, International Training Committee- 1993
Member, Steering Panel, International Training and Education Committtee-1997-5. Asian Oceanian Child Neurology Association
Australian Delegate - 1983- present.
Vice-President 1987-1994.
Member Steering Committee,
2nd Asian Oceanian Child Neurology Congress - 1986.
Member, Scientific Programme Committee AOCCN- 1990 and 1994.
6. Member Editorial Board,
Brain and Development, Tokyo.
7. Member Editorial Board,
Journal of Child Neurology, Littleton, Massachusetts, U.S.A.
8. Association Medicale Francophone d'Australie.
President - 1992-93.
INVITED OVERSEAS LECTURESHIPS:
International Symposium on Developmental Disabilities, Tokyo, 1977.
Master of Medicine Course, (Paediatrics), University of Singapore, 1977.
University of Indonesia, Jakarta, 1981.
International Symposium on Developmental Disabilities, Tokyo, 1981.
First Asian Oceanian Congress of Child Neurology, Taiwan, 1983.
Heritage Visiting Lectureship, University of Calgary, Canada, 1983.
Second International Conference on Charcot-Marie-Tooth Disease,
New York, 1987.
Sri Lankan Paediatric Association, Colombo, 1989.
International Paediatric Congress, Paris, 1989.
Airen Conference on Peripheral Neuropathy in Childhood, Geneva, 1989.
New Zealand Paediatric Association, 1989.
5th International Child Neurology Congress. Tokyo, 1990.
Plenary Lecturer, Joint Congress of the International Child Neurology
Association and Asian Oceanian Child Neurology Association, Tokyo, 1990.
Visiting Professor, Sheffield Children's Hospital, 1992.
New Zealand Paediatric Association, 1992.
AIDAB Lecturer, University Sains Malaysia, 1993.
Korean Child Neurology Association, 1994.
International Symposium (Fukuyama Festschrift), Tokyo, 1994.
Plenary Lecturer, Joint Congress of the International Child Neurology Association and the American Child Neurology Association, San Francisco, 1994.
Asian-Oceanian Child Neurology Association, Chieng Mai, 1994.
Carrell-Krusen Lecturer, Dallas, USA, 1995.
Choongqing University, China, 1996.
Asian- Oceanian Child Neurology Association, Istanbul, 1996.
Invited Professor, The University of Paris VII, 1996-1997.
International Symposium on Child Neurology, San Servolo, Venice, 1997.
Child Neurology Society of the Philippines, 1997.
Symposium on Neuromuscular Disorders, New Caledonia, 1998
Free University of Brussells 1999
ICNA Lecturer, Montevideo, 1999.
Lecturer and External Examiner, University of Malaysia, Kuala Lumpur, 1999
CURRENT AND PREVIOUS RESEARCH:
1. A major project has been a long-term and ongoing study
of chronic peripheral neuropathy in childhood. A thesis for the degree
of Doctor of Medicine in the University of Sydney was accepted in
1986. A textbook was published in 1990 (with J G McLeod and
J G Pollard). The Second Edition is with the publishers.
2. A second major area of current interest is the development
and validation of a screening test of higher mental function in
childhood (with J.Hendy, L.Bornholt and F. Black).
3. A study of CSF amino-acid and neurotransmitters in epilepsy
(with R. Goldsmith). Completed.
4. Various studies on anticonvulsant measurement and utilization in
childhood. Completed. Six papers published.PUBLICATIONS
BOOKS:
Ouvrier RA (Ed). Controversies in Childhood Epilepsy.
Excerpta Medica Sydney, 1986.
Ouvrier RA, McLeod JG, Pollard JD.
Peripheral Neuropathy in Childhood, Raven New York, 1990.
(Review: Iannaccone ST. J Child Neurol 1992; 7: 322-323).
Ouvrier RA, McLeod JG, Pollard JD.
Peripheral Neuropathy in Childhood, Second Edition, MacKeith Press, London 1999.
SCIENTIFIC ARTICLES:
Ouvrier RA, Hopkins IJ. "Occlusive disease of the vertebrobasilar arterial system in childhood".
Devel Med Child Neurol 1970; 12:186-192.
Ouvrier RA, Prineas J, Walsh JC, Reye RDK, McLeod JG."Giant axonal neuropathy - a third case". Proc Aust Assoc Neurol 1974;11:137..
Wise GA, Ouvrier R. "The Aicardi syndrome". Proc Aust Assoc Neurol 1974; 11: 103-113.
Ouvrier RA. "Plasma diphenylhydantoin Levels". Aust. N.Z.J. Med 1974; 4:524-525.
Ouvrier RA "CSF imaging in paediatrics. Med J Aust 1974; 2: 146-147.
McCaughan B, Ouvrier RA, de Silva M, McLaughlin AF. "The value of the brain scan and cerebral arteriogram in the Sturge-Weber syndrome". Proc Aust Assoc Neurol 1975; 12:185-190.
Prineas JW, Ouvrier RA, Wright RG, Walsh J C, McLeod JG. "Giant axonal neuropathy - a generalised disorder of cytoplasmic microfilament formation".
J Neuropath Exp Neurol 1976; 35: 459-470.
Ouvrier RA, Goldsmith R. "Phenobarbitone dosage in the neonate - preliminary communication".
Proc Aust Assoc Neurol 1977; 14:194-202.
Ouvrier RA. "Pertussis immunization - a neurologist's viewpoint". Med J Aust 1978; 2: 300-301.
*Ouvrier RA. Progressive dystonia with marked diurnal fluctuation". Ann Neurol 1978; 4: 412-417.
Ouvrier RA "The West and Lennox Syndromes" Asian Med J 1978; 21:516-523.
Hoyt CS, Billson F, Ouvrier RA, Wise GA. "Ocular features of Aicardi's syndrome".
Arch Ophthalmol 1978; 96:291-295.
Anthony JH, Procopis P, Ouvrier RA. "Benign acute childhood myositis". Neurology 1979; 29:1068-1071.
Procopis PG, Ouvrier RA. "Adrenoleukodystrophy: a study of four patients".
Clin Exp Neurol 1979;16:133.
Antony JH, Ouvrier RA, Wise GA. "Spasmus nutans: a mistaken entity". Arch Neurol 1980; 37: 373-375.
Murell WG, Ouvrier RA, Stewart BJ, Dorman DC. "Infantile botulism in a breast-fed infant from rural N.S.W". Med J Aust 1981;1:583.
Lewis D, Ouvrier RA, Procopis PG et al. "Bilateral optic nerve hypoplasia" Aust Paed J 1981; 17:48 (Abstract).
*Ouvrier RA, McLeod JG, Morgan GJ, Wise GA, Conchin TE. "Hereditary motor and sensory neuropathy of neuronal type with onset in early childhood". J Neurol Sci 1981; 51:181-197.
Goldsmith R, Ouvrier RA. "Salivary anticonvulsant levels in children: a comparison of methods".
Ther Drug Monitoring 1981; 3: 151-157.
Ouvrier RA, Lewis E, Procopis PG, Billson FA, Silink M, de Silva M. "Bilateral optic nerve hypoplasia". Clin Exp Neurol 18:52, 1981.
Procopis PG, Ouvrier RA. Sodium valproate: a five-year follow-up. Aust Paed J 1981; 5:85-94 (Abstract).
Paisley WJ, Ouvrier RA, Johnston I, Jones RFA, Sofer-Schreiber J, de Silva M. "Chronic spinal arachnoiditis in childhood". Devel Med Child Neurol 1982; 24: 798-804.
Ouvrier RA, Goldsmith R."The pharmacokinetics of phenobarbitone and phenytoin in the neonate".
In: Child Neurology. Proceedings of the TYDP International Symposium on Developmental Disabilities. ed. Fukuyama Y et al. Excerpta Medica, Amsterdam, 1982 pp 282-289.
Goldsmith R, Ouvrier RA, Procopis PG. Diurnal variation in anticonvulsant levels Aust Paed J 1982; 18:140-141 (Abstract).
*Ouvrier RA, Goldsmith RF. Phenobarbitone dosage in neonatal convulsions. Arch Dis Child 57:653-657, 1982.
*Ouvrier RA, McLeod JG, Conchin T. "Friedreich's ataxia: early detection and progression of peripheral nerve abnormalities". J Neurol Sci 1982; 55:137-145.
Ouvrier, R.A. "Some benign paroxysmal disorders of childhood". Aust Fam Physician 1983; 12: 389-392.
Sutton DL, Ouvrier RA. "Cerebral abscess in the under 6 month age group. Arch Dis Child 1983; 58: 901-905.
Ouvrier RA " Advances in neonatal neurology". Brain Dev 1984; 6: 520-527.
Sutton L, Ouvrier RA. "Headache in childhood" Aust Fam Physician 1985; 14:777-780.
Ouvrier RA "Chronic peripheral neuropathy". M.D. Thesis. University of Sydney, 1985.
Ouvrier RA, Billson FA. "Optic nerve hypoplasia: a review". J Child Neurol 1986; 1:181-8.
Ouvrier RA, McLeod JG, Conchin T. "Morphometric studies of sural nerve in childhood". Muscle Nerve 1986; 10:47-53.
Ouvrier, R.A. "Petit mal". In: Ouvrier, R.A. (Ed) Controversies in Childhood Epilepsy.
Excerpta Medica Sydney, 1986.
Cunningham A, Griffith N, Goldsmith R, Procopis P, Ouvrier RA, Bandler T. "Alterations in cerebrospinal fluid GABA in an experimental model of epilepsy" Aust Paed J 1986. (Abstract).
*Ouvrier RA, McLeod JG, Conchin TE. "The hypertrophic forms of hereditary motor and sensory neuropathy. A study of hypertrophic Charcot-Marie-Tooth disease (HMSN type I) and Dejerine-Sottas disease (HMSN type III) in childhood". Brain 1987; 110:121-148.
McElligot I, Ouvrier RA, Procopis PG. "Eyelid myoclonia". Aust NZ J Med 1988; 18:469 (Abstract)
Collins FA, Constantinou JE, Ouvrier RA, Procopis PG. Acute infectious polyneuropathy in children: a follow-up study. Aust J Paed 1988. 24: 66-67 (Abstract).
*Ouvrier RA, Billson F. "Benign paroxysmal tonic upgaze of childhood". J Child Neurol 1988; 3: 177-180.
Ouvrier RA, McLeod JG "Chronic peripheral neuropathy in childhood - an overview".
Aust Paed J Suppl. 1988; 24: 80-82.
De Jong APM, Haan EA, Manson JI, Wise GA, Ouvrier RA, Wadman SK. "Kinetic study of catecholamine metabolism in hereditary progressive dystonia". Neuropaediatrics 1989; 20: 3-11.
Constantinou J, Gillis J, Ouvrier RA, Rahilly PM. "Hypoxic- ischaemic encephalopathy after near miss sudden infant death syndrome". Arch Dis Child 1989; 64:703-708.
Ouvrier RA. "Giant axonal neuropathy - a review". Brain Dev 1989; 11:207-14.
North K, Ouvrier RA, Nugent M. "Pseudoseizures caused by hyperventilation resembling absence epilepsy". J Child Neurol 1990. 5: 288-94.
Macdonald WB, Tink AR, Ouvrier RA, Menser MA, de Silva LM, Naim H, Hawkes RA. "Japanese encephalitis after a two-week holiday in Bali" Med J Aust 1989; 150: 334-336.
Ouvrier RA. "Pallor of the optic disc in childhood". Aust NZ J Ophthalmol 1990;18: 375-379.
Ouvrier, R.A. "The hereditary peripheral neuropathies in childhood".
New Issues in Neurosciences 1990; 2:43-59.
Dhiravibulya K, Ouvrier RA, Johnston I H, Procopis P, Antony J. "Benign intracranial hypertension in childhood: a review of 23 patients". J. Paediatr. Child Health 1991; 27: 304-7.
Dewez P, North K, de Silva M, Ouvrier R, Isaacs D. " Fever and spastic quadriparesis caused by Mycoplasma pneumoniae". Ped Inf Dis J 1992; 11: 129-130.
Charuvanij A, Ouvrier RA, Procopis PG, Antony JH, Fagan ER. " ACTH treatment in intractable seizures of childhood". Brain Devel 1992: 14: 102-106.
Reutens D, Bye A, Hopkins I, Danks A, Somerville E, Walsh J, Bleasel A, Ouvrier R, McKenzie R, Manson J, Bladin P, Berkovic S. "Corpus callosotomy for intractable epilepsy: seizure outcome and prognostic factors". Epilepsia 1993; 34: 904-909.
North KN, Ouvrier RA, McLean CA, Hopkins IJ. "Idiopathic hypothalamic dysfunction with dilated unresponsive pupils". J Child Neurol 1994; 9: 320-325.
North K, Kan A, de Silva M, Ouvrier R. "Hemiplegia due to posterior cerebral artery occlusion".
Stroke 1993; 24: 1757-1760.
Kozlowski K, Ouvrier RA. "Agenesis of the corpus callosum with mental retardation and osseous lesions. Am J. Med. Genet 1993; 48: 6-9.
*Ouvrier RA, Goldsmith RF, Ouvrier S, Williams IC. "The Value of the Mini-Mental State Examination in childhood: a preliminary study". J. Child Neurol 1993; 8:145-8
Ouvrier, R.A. "Henri Parinaud and his syndrome". Med J Aust 1993; 158:711-3
Hayasaka K, Himoro M, Sawaishi Y, Nanao K, Takahashi T, Takada G, Nicholson G.A., Ouvrier, R.A., Tachi N. "De novo mutation of the myelin Po gene in Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III)" Nature Genetics 1993; 5: 266-268.
Ouvrier RA, Nicholson GA. "Advances in the genetics of hereditary hypertrophic neuropathy in childhood". Brain Devel 1995; suppl 17: 31-37.
*Ouvrier R, Nunn K, Sprague T, McLean C, Arbuckle S, Hopkins I, North K."Idiopathic hypothalamic dysfunction: a paraneoplastic syndrome" Lancet 1995; 346: 1298 (Letter)
Valentijn LJ, Ouvrier RA, van den Bosch NH, Bolhuis PA, Baas F, Nicholson GA. "Dejerine-Sottas neuropathy is associated with a de novo PMP22 mutation". Hum Mutation. 1995; 5: 76-80.
*Ouvrier R "Correlation between the histopathologic, genotypic, and phenotypic features of hereditary peripheral neuropathies in childhood" J Child Neurol 1996; 11: 133-146.
Ouvrier RA "Hereditary neuropathies in children: the contribution of the new genetics". Sem Ped Neurol 1996; 3: 140-151.
O'Meara M, Ouvrier R. "Viral encephalitis in children". Curr Opin Ped 1996; 8: 11-15.
Grattan-Smith PJ, Morris JG, Johnston HM, Yiannikas C, Malik R, Russell R, Ouvrier RA "Clinical and neurophysiological features of tick paralysis". Brain 1997;120: 1975-1987.
Ikegami T, Nicholson G, Ikeda H, Ishida A, Johnston H, Wise G, Ouvrier R, Hayasaka K. "A novel homozygous mutation of the myelin Po gene producing Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III)". Biochem Biophys Res Commun 1996; 222: 107-110
Manomani V, Ouvrier RA. "Intravenous immunoglobulin treatment in childhood Guillain-Barré Syndrome". Dev Med Child Neurol 1997; 39: 425(Letter).
Murofushi T, Ouvrier RA, Parker GD, Graham RI, da Silva M, Halmagyi GM. "Vestibular abnormalities in CHARGE association". Ann Otol Rhinol Laryngol 1997;106: 129-134.
Nunn K, Ouvrier R, Sprague T, Arbuckle S, Docker M."Idiopathic hypothalamic dysfunction: a paraneoplastic syndrome?" J Child Neurol 1997; 12: 276-281.
Howe AM, Lipson AH, de Silva M, Ouvrier R, Webster WS. "Severe cervical dysplasia and nasal cartilage calcification following prenatal warfarin exposure". Am J Med Genet 1997; 71: 391-396.
Sander S, Ouvrier RA, Nicholson G, Pollard JD McLeod JG. "The clinical and
histopathological features of MPZ and PMP22 mutations". Proceedings of the Peripheral Nerve Society Cambridge 1997. (Abstract).
Hayes M, Ouvrier RA, Evans W, Somerville E, Morris JGL. X-linked dystonia-deafness syndrome. Movement Disorders 1998; 13: 303-308.
Ikegami T, Nicholson G, Ouvrier R, et al.(1998) De novo mutation of the myelin Po gene in Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III): two amino acid insertion after Asp 118. Human Mutation: Suppl.1: S103-105 .
Ng Y, Wu T, Ouvrier RA. "Drug therapy in juvenile dermatomyositis. A follow-up study". J Child Neurol 1998; 13: 109-112.
Ouvrier RA Progrès en génétique des neuropathies périphériques chez l'enfant. Arch Pédiatr 1998; 5: 480-483.
Ouvrier RA The hypomyelinating neuropathies of mice and men. Rev Neurol (Paris) 1998; 154: 481-487.
Ouvrier RA "Update on acute and chronic inflammatory polyneuropathy" J Child Neurology 1999; 4: 53-57.
BOOK CHAPTERS:
Ouvrier RA, Freeman JM, McKhann G. "The value of cerebrospinal fluid imaging in paediatrics" in Paediatric Nuclear Medicine. Ed. A.E. James, W.B. Saunders, Philadelphia, 1974.
Ouvrier RA, North K, Nugent M, Vignaendra V. "Pseudoseizures resembling petit mal caused by hyperventilation". Grey Areas in Epilepsy. Ed. F. Vajda & G. Donnan, York. Melbourne, 1985.
Ouvrier RA. "Migraine versus epilepsy". In: Epilepsy, A Symposium. Ed. N. A Symposium. Sydney. 1988;7-9.
Goldsmith RF, Earl JW, Ouvrier RA, Procopis P, Cunningham A. "CSF amino acids in childhood epilepsy" In: Amino Acids, Chemistry, Biology and Medicine. Ed Lubec G, Rosenthal G.A. Escom Leiden 1990; pp 415-21.
Ouvrier RA. "Cerebral Palsy" In: A Textbook of Paediatrics. 2nd Edition.
Ed. by M. Robinson, Churchill Livingstone, Melbourne, 1990.
Ouvrier RA, McLeod JG. "Hereditary motor and sensory neuropathy type 111". In: Charcot-Marie-Tooth Disorders - Pathophysiology, Molecular Genetics and Therapy. Ed. R.E. Lovelace and H.K. Shapiro. Wiley Liss, New York, 1990.
Ouvrier RA, McLeod JG. "Hereditary sensory neuropathy. In: J.M.B.V. De Jong ed. Handbook of Clinical Neurology. Vol.60: Elsevier. Amsterdam 1991, pp 5-22.
Ouvrier RA. "Peripheral neuropathies in childhood" In: Fetal and Perinatal Neurology. Eds: Y.Fukuyama, Y.Suzuki, S.Kamoshita, P.Casaer. Karger Basel, 1992 pp 60-78.
WORK IN PRESS
Ouvrier RA and Collins K Cerebral palsy and degenerative diseases. In : Robertson M and Roberton D Eds. Practical Paediatrics. 1999 In press.
Smith S Ouvrier RA. Peripheral Neuropathy in: Swaiman K (Ed.) Pediatric Neurology 1999. In press.
WORK COMPLETED
Sander S Nicholson GA Ouvrier RA McLeod JG Pollard JD."Charcot-Marie-Tooth disease: histopathological features of the peripheral myelin protein (PMP22) duplication (CMT1A) and Connexin mutations (CMTX1)". Muscle Nerve 1998. Manuscript accepted.
*Ouvrier R, Hendy J, Bornholt L, Black F. "The development of SYSTEMS: Sydney Screening Test for the Evaluation of Mental Status". J Child Neurol In press 1999
©2001 Ph. Evrard
