Biographies
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Pr. Alain VERLOES
VERLOES, Alain, Roger, Constant, né à Etterbeek, le 30 juin 1957
Nationalité : belge
Epouse Aïcha AGUELMIN, infirmière
Enfants : Alia (28.11.89), Arnaud (27.11.92), Alice (03.09.98)
Adresse : 13 Chaussée de Liège
4160 ANTHISNES
Tel 04-383. 66. 99
B. ETUDES MEDICALES
Médecine: diplome de docteur en Médecine , Chirurgie et Accouchements (1982), Université Libre de Bruxelles, mention: "Avec la plus grande distinction"
Pédiatrie: Formation à l'Université de l'Etat à Liège (Professeur F. Geubelle)
Reconnaissance INAMI de spécialiste en Pédiatrie en Janvier 1989, sous le numéro 1/64684/22/690. Reconnaissance de la compétence spéciale en néonatologie en 1997.
C. FORMATION EN GENETIQUE
Stage à la Clinique de Génétique Médicale de l'Hôpital des Enfants-Malades, Paris (service du Professeur Jean Frézal) du 1-X-1986 au 30-IX-1987.
Certificat d'Enseignement Spécialisé de Génétique Humaine Générale de l'Université René Descartes - Paris 5 - mention "bien" (1987).
Diplôme Universitaire de Foetopathologie - Université Pierre et Marie Curie - Paris 6 (1990). (Mémoire: «La dermopathie restrictive. A propos de deux observations.» défendu le 12 Octobre 1990)
D. CURSUS ACADEMIQUE
1) Grades académiques
Agrégé de l'Enseignement Supérieur (1997). Titre de la thèse: «Apports de l'étude des syndromes rares ou exceptionnels en génétique humaine»
Professeur de Clinique depuis 1er Janvier 1998
2) Enseignement universitaire
"Malformations congénitales, maladies génétiques et erreurs du métabolisme" (10 h). Cours créé en 1996
«Epidémiologie génétique». 2me licence en Santé Publique (15 heures) Cours créé en 1998
3) Membre Conseil Supérieur de Génétique (Ministère National de la Santé Publique et de l'Environnement) (nomination: A. R. du 14/09/92).
E. ACTIVITES HOSPITALIERES
Rang et affiliation actuels: chef de Clinique, service de Génétique du CHU de Liège
Fonctions
1) Responsable des consultations de Génétique Clinique dépendant du Centre de Génétique de Liège. Ces consultations couvrent tous les domaines de la Génétique Médicale (génétique «assique» de l'adulte et de l'enfant, diagnostic prénatal, diagnostic présymptomatique, oncogénétique). Elles sont assurées au CHU du Sart Tilman, au CHR de la Citadelle, et sur 12 sites hospitaliers périphériques, situés dans les provinces de Liège, de Luxembourg et du Hainaut. Ce réseau de consultation a été créé à mon instigation. Au total, ces consultations me permettent de voir approximativement 900 nouvelles familles par an, et de revoir environ 450 patients/familles en follow up.
2) Directeur du Centre Universitaire Wallon de Génétique Maladies métaboliques: reconnaissance INAMI en Janvier 1999
3) Superviseur du laboratoire de biochimie génétique et du centre de dépistage par tests multiples (dépistage néonatal sur sang sèché et Triple Test)
4) Superviseur des autopsies foetales et néonatales, en collaboration avec le service d'anatomopathologie du CHU.
F. ACTIVITE DE RECHERCHE
Mes travaux de recherche sont essentiellement cliniques. Ils concernent:
· la syndromologie des associations polymalformatives (avec ou sans dysmorphies)
· l'arriération mentale d'origine génétique.
Ces travaux portent sur la définition, la classification, la nosologie et/ou le déterminisme génétique (ou cytogénétique) d'affections exceptionnelles.Ils m'ont permis de décrire plusieurs "nouveaux" syndromes. Plusieurs articles résultent de collaborations nationales interuniversitaires, ou de collaborations internationales avec des collègues Français, Suisses, Britanniques et Américains. Ils ont débouché sur de nombreuses publications et forment notemment le substrat de ma thèse d'agrégation.
La reconnaissance de la qualité de ces travaux par la communauté des dysmorphologistes m'a permis
1) d'être un membre régulier des réunions de Dysmorphologies «rmées» (sur invitation) anglosaxonnes:
· Manchester Dysmorphology Meeting (Manchester, Grande-Bretagne)
· David Smith Workshop on Malformation and Morphogenesis (USA)
2) d'être membre du Comité de lecture de Clinical Dysmorphology et du comité scientifique d'ORPHANET (INSERM SC11), section dysmorphologie.
3) d'agir en tant que reviewer régulier pour les journaux suivants: J Med Genet, Am J Med Genet, Clinical Dysmorphology, Clin Genet, Genet Counsel, European Journal of Human Genetics.
G. BIBLIOGRAPHIE
La liste complète comporte actuellement 122 articles publiés dans des revues internationales avec comité de lecture, dont 65 environ comme premier auteur. Le facteur d'impact cumulé de ces 122 publications est de 227, sur base des FI de 1997. La liste des publications entre 1989 et 1999 figure dans un fichier texte ci-annexé.
Verloes A, Lambotte C (1989). Further delineation of a syndrome of Coloboma, Oligophrenia, Ataxia, Cerebellar vermis hypo/aplasia and Hepatic fibrosis. Am J Med Genet 32:237-242.
Verloes A, Delfortrie J, Lambotte C (1989). The GOMBO syndrome of Growth retardation, Ocular abnormalities, Microcephaly, Brachydactyly, and Oligophrenia. Am J Med Genet 32:15-18.
Verloes A, Dresse MF, Jovanovic M, Geubelle F (1989). 3C syndrome. Third Occurrence of Cranio-Cerebello-Cardiac Dysplasia (Ritscher-Schinzel syndrome). Clin Genet 35:205-208.
Verloes A, Herens C, Retz MC, Van Maldergem L, Dodinval P (1989). Exencephaly in Roberts-SC phocomelia. Ann Génet 32:169-170.
Herens C, Pierquin G, Verloes A, Schaaps JP, Frederic J (1989). Mosaicism of 46,XX/47,XX,+9/47,XX,+?mar in the same amniotic fluid with apparent loss of one cell line after delivery. Prenat Diag 9:373-375.
Rigo J, Verloes A, Senterre J (1989). Plasma aminoacid concentration in term infants fed human milk, a whey predominant formula, or a whey hydrolysate formula. J Pediatr 115:752-755.
Verloes A, Soyeur-Broux M, Arrese-Estrada J, Piérard-Franchimont C, Piérard G. (1990). Poikiloderma, alopecia, retrognathism and cleft palate: the PARC syndrome. Dermatologica 181:142-144.
Verloes A, Frikiche A, Paquay T, Gremillet C, De Cortis T, Rigo T, Senterre J (1990). Proximal phocomelia and radial ray aplasia after prenatal exposure to valproic acid. A case report. European J Pediatr 149:266-267.
Verloes A, Emonts P, Dubois JP, Senterre J (1990). Paraplegia and arthrogryposis after prenatal exposure to ergotamine. J Med Genet 27:213-214.
Verloes A, Dodinval P (1990). Rieger anomaly and uveal coloboma with associated anomalies. Third observation of a rare oculo-palato-osseous syndrome -the Abruzzo-Erikson syndrome. Ophthalm Paediatr Genet 11:41-47.
Verloes A, Dodinval P, Beco J, Lambotte C (1990). Lambotte syndrome : A new recessively inherited MCA/MR syndrome with severe brain malformations. Am J Med Genet 37:119-123.
Verloes A, Dodinval P, Bonnivert J, Lambotte R (1990). Etretinate embryotoxicity 7 months after discontinuing treatment. Am J Med Genet 37:119-123.
Verloes A, Van Maldergem L, de Marneffe P, Dufier J, Maroteaux P (1990). Microspherophakia-metaphyseal dysplasia. A "new" dominantly inherited bone dysplasia with severe eye involvement. J Med Genet 27:467-471.
Verloes A, Pierard GE, Le Merrer M, Maroteaux P (1990). Recessive metaphyseal dysplasia without hair involvement. J Med Genet 27:693-696.
Herens C, Verloes A, Laloux F, Van Maldergem L, Koulischer L (1990). Trisomy 20q. A new case and further phenotypic delineation. Clin Genet 37:363-366.
Piérard GE, Soyeur-Broux M, Arrese Estrada J, Piérard-FranchimontC, Soyeur D, Verloes A (1990). Cutaneous presentation of the cardio-facio-renal syndrome. J Am Acad Dermatol 22:920-922.
Ramaekers PR, Legius E, Verloes A, Gillerot Y, Vandenberghe K, Fryns JP (1990). Holoprosencephaly and postaxial polydactyly with normal chromosomes. Another observation of a new malformation syndrome. Eur J Obstet Gynecol Repr Biol 36:161-165.
Van Maldergem L, Gillerot Y, Salmin E, Verloes A, Koulischer L (1990). Lethal short rib with median cleft and without polydactyly: a fourth case. Pediatr Radiol 20:367-368.
Verloes A, Gillerot Y, Delfortrie J, Zeevaert-Arnold MT, Collard R, Koulischer L, Fryns JP (1991). Male pseudohermaphroditism with persistent Müllerian structures, mental retardation and Borjeson-Forssman-Lehmann - like features : a new syndrome? Genet Counsel, 38, 210-217.
Verloes A, Schaaps JP, Soyeur D, Hustin J, Herens C, Koulischer L (1991) Chorioangioma and hygroma colli revealing Wolf-Hirschhorn syndrome. Prenat Diag 11:129-132.
Verloes A, Dodinval P, Retz MC, Schaaps JP, Koulischer L (1991). A hydropic fetus with translucent ribs, arthrogryposis multiplex congenita and congenital myopathy : etiological heterogeneity of A. M. C. , Toriello-Bauserman type. Genet Counsel 2:63-66.
Verloes A, Le Merrer M, Farriaux JP, Maroteaux P (1991). Metaphyseal acroscyphodysplasia. Clin Genet 39:362-369.
Verloes A, Aymé S, Gambarelli D, Gonzales M, Le Merrer M, Mulliez N, Philip N, Roume J (1991). Holoprocencephaly and polydactyly ("pseudo-trisomy 13") syndrome: a syndrome with features of hydrolethalus and Smith-Lemli-Opitz syndromes. A collaborative multicentre study. J Med Genet 28:297-303.
Verloes A, Massart B, Jossa V, Langhendries JP, Hainaut H, Paquot JP, Koulischer L (1991). Neuroblastoma in a dwarfed newborn. Possible clue to the chromosomal localization of the gene for achondroplasia ?. Ann Génet, 34:25-26.
Verloes A, Seret N, Bernier V, Gonzales M, Herens C, Koulischer L (1991). Branchial arch anomalies in trisomy 18. Ann Génet 34:22-24.
Ben Mosbah T, Piérard-Franchimont C, Verloes A, Goffin F, Lesuisse M, Dodinval P, Piérard GE (1991). Le syndrome de Protée et ses altérations conjonctives cutanées. Giornale Internationale de Dermatologia Pediatrica 3;83-88.
Gibson KM, Sherwood WG, Hoffmann GF, Stumpf DA, Dianzani I, Schutgens RBH, Barth PG, Weismann U, Bachmann C, Schynemackers-Pitance P, Verloes A, Narisawa K, Mino M, Ohya N, Kelley RI (1991). Phenotypic heterogeneneity in the syndromes of 3-methylglutaconic aciduria. J Pediatr 118:885-890.
Maroteaux P, Verloes A, Stanescu V, Stanescu R (1991). Metaphyseal anadysplasia: a metaphyseal dysplasia of early onset with radiological regression and benign course. Am J Med Genet 39:4-10.
Schoos R, Dodinval-Versie J, Verloes A, Lambotte C, Koulischer L (1991). Alpha-1-antitrypsin neonatal screening on dried blood by ELISA. Report of 39289 newborns. Clin Chem 37:821-825.
Van Maldergem L, Avni F, Mossay B, Herens C, Verloes A, Gillerot Y (1991). Ring chromosome 9 in a newborn male presenting with facial dysmorphia, hypospadias and skeletal abnormalities. Genet Counsel 2;123-127.
Van Maldergem L, Espeel M, Roels F, Petit C, Dacremont G, Wanders RJA, Verloes A, Gillerot Y (1991). X-linked recessive chondrodysplasia punctata with XY translocation in a stillborn fetus. Hum Genet 87:661-664.
Verloes A, Gillerot Y, Walczak E, Van Maldergem L, Koulischer L (1992). Acromelic frontonasal "Dysplasia". Further delineation of a subtype with brain malformation and polydactyly (Toriello syndrome). Am J Med Genet 42:180-183.
Verloes A, Le Merrer M, Davin JC, Wittamer P, Abrassart C, Bricteux G, Briard ML (1992). The orocraniodigital syndrome of Juberg and Hayward. J Med Genet 29:262-265 .
Verloes A, Mulliez N, Gonzales M, Laloux F, Hermanns-Lê T, Piérard GE, Koulischer L (1992). Restrictive dermopathy. A lethal form of arthrogryposis multiplex with skin and bone dysplasias : three new cases and review of the literature. Am J Med Genet 43:539-547.
Verloes A, Le Merrer M (1992). Lumping of CFC and Baraitser-Patton Noonan-like syndrome. Am J Med Genet 42:756.
Verloes A, Gillerot Y, Langhendries JP, Fryns JP, Koulischer L (1992). Variability versus Heterogeneity in syndromal Hypothalamic Hamartoblastoma and related disorders. Review and Delineation of the Cerebro-Acro-Visceral-Early lethality (CAVE) multiplex Syndrome. Am J Med Genet 43:669-677.
Verloes A, Schoos R, Koulischer L (1992). Non-radioactive assay od AFP, HCG and uE3 on dried blood specimen : a low cost alternative for the maternal screening for Trisomy 21. Prenat Diag 12:1073-1074. .
Verloes A, Hermia JP, Galand A, Koulischer L, Dodinval P (1992). Glaucoma-lens Ectopia-Microspherophakia-Stiffness-Shortness (GEMSS) syndrome. A dominant syndrome with features of Weill-Marchesani and Moore-Federman syndrome. Am J Med Genet 44:48-51.
Verloes A, Koulischer L (1992). New oral-acral syndrome with partial agenesis of the maxillary bones. Am J Med Genet 44:605-607.
Lapière JC, Verloes A, Herens C, Delfortrie J, Van Maldergem L, Gillerot Y, Koulischer L (1992). Combined 10pter-p11 and 18pter-q11 trisomy in a 7-year-old child. Genet Counsel 3,155-159
Piérard-Franchimont C, Piérard GE, Hermanns-Lê T, Arrese Estrada J, Verloes A, Mulliez N (1992). Dermatopathological aspects of restrictive dermopathy. Am J Surg Pathol 166:223-228.
Scalais E, Verloes A, Sacré JP, Piérard GE, Rizzo WB (1992). Sjögren-Larsson-like syndrome with bone dysplasia and normal fatty alcohol NAD+ oxydoreductase activity. Pediatric Neurology 8:459-465.
Van Maldergem L, Wetzburger C, Verloes A, Fourneau C, Gillerot Y (1992). Mental retardation with blepharonasofacial abnormalities and hand malformations : a new syndrome ? Clin Genet 41:22-24.
Van Maldergem L, Verloes A, Lejeune L, Gillerot Y (1992). The Baller-Gerold syndrome. J Med Genet 29:266-268.
Verloes A, Elmer C, Lacombe D, Heinrichs C, Rebuffat E, Demarquez JL, Moncla A, Adam E (1993). Ondine-Hirschsprung syndrome (Haddad syndrome). Further delineation in two cases and review of the literature. Eur J Pediatr 152:75-77.
Verloes A, Bonneau D, Guidi O, Berthier M, Oriot D, Van Maldergem L, Koulischer L (1993). Brachymorphism-Onychodysplasia-Dysphalangy syndrome. J Med Genet 30:158-161.
Verloes A, Moës D, Palumbo G, Elmer C, François A, Bricteux G (1993). Schinzel-Giedion syndrome. Eur J Pediatr 152:421-423.
Verloes A, Journel H, Elmer C, Misson JP, Le Merrer M, Kaplan J, Van Maldergem L, Deconinck H, Meire F, (1993). Heterogeneity versus variability in megalocornea-mental retardation (MMR) syndromes. Report of new cases and delineation of 4 probable types. Am J Med Genet 46:132-137.
Verloes A (1993). Iris coloboma, ptosis, hypertelorism and mental retardation : Baraitser-Winter syndrome or Noonan syndrome ? . J Med Genet 30:425-426.
Verloes A, Bricteux G, Koulischer L. (1993). Pseudo-aminopterin syndrome. Am J Med Genet 46:394-397.
Hustinx R, Verloes A, Grattagliano B, Herens C, Jamar M, Soyeur D, Schaaps JP, Koulischer L (1993). Monosomy 11q. Report of two familial cases and review of the literature. Am J Med Genet 47:312-317.
Lacombe D, Bonneau D, Verloes A, Couet D, Koulischer L, Battin J (1993). Lujan-Fryns syndrome (X-linked mental retardation with Marfanoid habitus) : report of three cases and review. Genet Counsel 4: 193-198.
Verloes A, Ernould C, Dubru JM, Malchair R, Koulischer L (1994). Diabetes mellitus, mental retardation, lipodystrophy and dysmorphic traits. Clin Dysmorphol 3: 160-163.
Verloes A (1994). Severe acrocallosal syndrome or acromelic frontonasal dysplasia ? Am J Med Genet 49, 306.
Verloes A, Narcy F, Grattagliano B, Delezoide A, Guibaud P, Schaaps JP, Le Merrer M, Maroteaux P (1994) Osteocraniostenosis. J Med Genet 31: 772-778
Verloes A (1994). Hypertelorism-microtia-clefting syndrome. Genet Counsel 5: 283-287
Edery P, Pelet A, Mulligan LM, Abel L, Attié T, Dow E, Bonneau D, David A, Flintoff W, Jan D, Journel H, Lacombe D, LeMerrer M, Meijers C, Parent P, Philip N, Plauchu H, Sarda P, Verloes A, Nihoul-Fékété C, Williamson R, Ponder BAJ, Munnich A, Lyonnet S (1994) Long segment and short segment familial Hirschsprung's disease : variable clinical expression at the RET locus. J Med Genet 31:602-606.
Schrander-Stumpel C, Meinecke P, Wilson G, Gillessen-Kaesbach G, Tinschert S, König R, Phillip N, Rizzo R, Schrander J, Pfeiffer L, Maat-Kievit A, van der Burgt I, van Essen T, Latta E, Hillig U, Verloes A, Journel H, Fryns JP (1994). The Kabuki (Niikawa-Kuroki) syndrome : further delineation of the phenotype in 27 non-japanese patients. Eur J Pediatr 153:438-445.
Verloes A, Narcy F, Fallet-Bianco C (1995). Syndromal hypothalamic hamartoblastoma with holoprosencephaly sequence, microphthalmia, pulmonary malformations, radial hypoplasia and Müllerian regression. Further delineation of new syndrome ? Clin Dysmorphol 4:33-37.
Verloes A, David A (1995). Dominant mesomelic shortness of stature with acral synostoses, umbilical anomalies, and soft palate agenesis. Am J Med Genet 55. 205-212
Verloes A (1995). Numerical syndromology. A mathematical approach to the nosology of complex phenotypes. Am J Med Genet 55. 433-443
Verloes A, Schoos R, Herens C, Vintens A, Koulischer L (1995). A prenatal Trisomy 21 screening program using AFP, hCG and uE3 on dried blood. Am J Obstet Gynaecol 172: 167-174.
Verloes A, Sakalihasan N, Limet R, Koulischer L (1995). Aneurysms of the abdominal aorta. A familial and genetic study in three hundred thirteen pedigrees. J Vasc Surg 21, 646-655.
Verloes A, Massart B, Dehalleux I, Langhendries JP, Koulischer L (1995). Diagnostic pittfall : a child overlapping Beckwith-Wiedemann, Perlman, Denys-Drash and Simpson-Golabi-Behmel syndromes. Clin Genet 47:257-262. .
Verloes A, Misson JP, Dubru JM, Jamblin P, LeMerrer M (1995). Heterogeneity of SPONASTRIME dysplasia: delineation of a variant form with mental retardation Clin Dysmorphol 4, 208-215
Verloes A, David A, Ngô L, Bottani A (1995). Stringent delineation of Pallister-Hall syndrome (stricto sensu) in 2 long-surviving patients: importance of radiological anomalies of the hands. J Med Genet 32, 605-611
Verloes A, David A, Odent S, Toutain A, André MJ, Lucas J, Le Marec B (1995). Opitz GBBB syndrome: chromosomal rvidence of an X-linked form. Am J Med Genet. Am J Med Genet 59, 123-128.
Bottani A, Verloes A (1995) The Myhre-GOMBO syndrome: possible lumping of two "old" new syndromes ? Am J Med Genet 59, 523-4.
Ectors FJ, Koulischer L, Jamar M, Herens C, Verloes A, Remy B, Beckers JF (1995). Cytogenetic study of bovine oocytes matured in vitro. Theriogenology 44:445-450.
Gilbert-Dussardier B, Bonneau D, Gigarel N, Le Merrer M, Bonnet D, Philip N, Serville F, Verloes A, Rossi A, Aymé S, Weissenbach J, Mattéi MG, Lyonnet S, Munnich A (1995) A novel microsatellite DNA marker at locus D7S1870 detects hemizygocity in 75 % of patients with Williams syndrome. Am J Hum Genet 56:542-543
Lacombe D, Pedespan JM, Fontan D, Chateil JF, Verloes A (1995). Phenotypic variability in Van Der Woude syndrome. Genet Counsel 6,221-226.
Verloes A, Jamblin P, Koulischer L, Bourguignon JP (1996). A new form of skeletal dysplasia with amelogenesis imperfecta and platyspondyly. Clin Genet 49, 2-5.
Verloes A, Temple IK, Hubert AF, Hope P, Gould S, Debauche C, Verellen G, Deville JL, Koulischer L, Sokal E (1996). Recurrence of neonatal hemochromatosis in half-sibs born from unaffected mothers. J Med Genet 33: 444-449
Verloes A, Lesenfants S, Philippet B, Iyawa A, Laloux F, Koulischer L (1996). Microcephaly, macrotia, unusual mimics and mental retardation new syndrome or variant of de Lange type 2 syndrome. Genet Counsel 7: 277-282.
Verloes A, Sakalihasan N, Limet R, Koulischer L (1996). Genetic aspects of abdominal aortic aneurysm. Ann NY Acad Sci 800, 44-55
Biesecker LG, Abbott M, Allen J, Clericuzio C, Feuillan P, Graham J Jr, Hall J, Kang S, Haskins Olney A, Lefton D, Neri G, Peters K, Verloes A (1996). Report of the workshop on Pallister-Hall and related phenotypes. Am J Med Genet 65:76-81.
Bürglen L, Amiel J, Viollet L, Lefebvre S, Burlet P, Clermont O, Raclin V, Landrieu P, Verloes A, Munnich A, Melki J (1996). SMN gene deletion in the arthrogryposis multiplex congenita-spinal muscular atrophy association. J Clin Invest 98:1130-1132
David A, Mercier J, Verloes A (1996). Child with manifestations of Nager acrofacial dysostosis, and the MURCS, VACTERL, and pulmonary agenesis associations : complex defect of blastogenesis? Am J Med Genet 61, 1-5.
David A, Nombalais MF, Rival JM, Verloes A (1996). Nosology of fetal hypokinesia sequence based on CNS abnormalities: is there an Aase-Smith syndrome? Clin Genet 50, 251-254
Narbay G, Meire F, Verloes A, Casteels I, Devos E (1996). Ocular manifestations in Delleman syndrome (oculocerebrocutaneous syndrome, OCC-syndrome) and encephalocraniocutaneous lipomatosis (ECCL) - report of three cases. Bull Soc Belg Ophtalmol 261:65-70.
Verloes A, Lesenfants S (1997). A new form of mandibulofacial dysostosis with macroblepharon and macrostomia. Clin Dysmorphol 6:21-24.
Verloes A (1997). Osteocraniostenosis vs. Hallermann-Streiff-François syndrome. Am J Med Genet 64:105-107.
Verloes A, Lombet J, Lambert Y, Hubert AF, Deprez M, Fridman V, Gosseye S, Rigo J, Sokal E (1997). Tricho-hepato-enteric syndrome: further delineation of a distinct form of neonatal hemochromatosis with intractable diarrhoea, and hair anomalies. Am J Med Genet 68:391-395.
Verloes A, Lesenfants S, Misson JP, Galand A, Koulischer L (1997). Microcephaly, muscular build, rhizomelia and cataracts: a possible recessive syndrome, and some comments on the use of electronic databases in syndromology. Am J Med Genet 68:455-460.
Verloes A, Temple IK, Bonnet S, Bottani A (1997). Coloboma, mental retardation, hypogonadism and obesity: critical review and updated nosology of the so called «Biemond syndrome type 2», updated nosology, and delineation of three «w» syndromes. . Am J Med Genet 69:370-379.
Verloes A, Massin M, Lombet J, Grattagliano B, Soyeur D, Rigo J, Koulischer L, Van Hoof F (1997): Nosology of lysosomal glycogen storage diseases without in vitro acid maltase deficiency: delineation of a neonatal form. Am J Med Genet 72: 135-142.
Verloes A, Maquet P, Sadzot B, Vivario M, Thiry A, Franck G Nasu-Hakola syndrome (1997) : polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy. J Med Genet 34:753-757.
Courtens W, Levi S, Verbelen F, Verloes A, Vamos E (1997) : Feingold syndrome : report of a new family and review. Am J Med Genet 60:55-60.
Gladwin A, Donnai D, Metcalfe K, Schrander-Stumpel C, Brueton L, Verloes A, Aylsworth A, Toriello H, Winter R, Dixon M (1997). Localization of a gene for oculodentodigital syndrome to human chromosome 6q22-q24. Hum Mol Genet 6:123-127.
Herens C, Jamar M, Alvarez-Gonzalez ML, Lesenfants S, Lombet J, Bonnivert J, Koulischer L, Verloes A (1997). Private multiple congenital anomaly syndromes may result from unbalanced subtle translocations: t(2q;4p) explains the Lambotte syndrome.Am J Med Genet 73:127-131
Koulischer L, Verloes A, Lesenfants S, Jamar M, Herens C (1997) : Genetic risk in natural and medically assisted procreation. Early Pregn Biol Med 3:164-171.
Verloes A, Curry C, Jamar M, Herens C, O'Lague P, Marks J, Sarda P, Blanchet P (1998): Juvenile rheumatoid arthritis and del(22q11) syndrome: a non-random association. J Med Genet 35:943-947
de Silva D, Verloes A (1998): Further delineation of the Verloes-Koulischer-oro-acral syndrome. Am J Med Genet 80:535-537.
Gelb BD, Willner JP, Dunn TM, Kardon NB, Verloes A, Poncin J, Desnick RJ (1998) Paternal Uniparental Disomy for Chromosome 1 Revealed by Molecular Analysis of a Patient with Pycnodysostosis. Am J of Hum Genet 62:848-854
Leroy JG, Nuytinck L, De Paepe A, De Rammelaere M, Gillerot Y, Verloes A, Loeys B, De Groote W (1998): Bruck syndrome: neonatal presentation and natural course in three patients. Pediatr Radiol 28:781-789
Limet R, Nusgens B, Verloes A, Sakalihasan N (1998): Pathogenesis of abdominal aortic aneurysm (AAA) formation. Acta Chir Belg 98:195-198.
Odent S, Le Marec B, Toutain A, David A, Vigneron J, Tréguier C, Jouan H, Milon J, Fryns JP, Verloes A (1998). Central nervous system malformations and early end-stage renal disease in oro-facio-digital syndrome type I: a review. Am J Med Genet 75:389-394.
Plomp AS, Hamel BC, Cobben JM, Verloes A, Offermans JP, Lajeunie E, Fryns JP, de Die-Smulders CE (1998). Pfeiffer syndrome type 2: further delineation and review of the literature. Am J Med Genet 75:245-251.
Van Coster RN, Janssens S, Misson JP, Verloes A, Leroy JG (1998): Prenatal diagnosis of pyruvate carboxylase deficiency by direct measurement of catalytic activity on chorionic villi samples. Prenat Diagn 18:1041-1044.
Verloes A, Stevenaert A, Teh BT, Petrossians P, Beckers A (1999) : Familial acromegaly : case report and review of the literature. Pituitary 1 : 273-277.
Verloes A, Hermanns-Lê T, Lesenfants S, Lombet J, Lamotte PJ, Crèvecoeur-Liégeois C, Duchesne B, Piérard GE (1999) : Koraxitrachitic Syndrome : a syndromic form of self-healing collodion baby with residual dappled atrophy of the derma. Am J Med Genet 86 : 454-458.
David A, Bitoun P, Lacombe D, Lambert JC, Nivelon A, Vigneron J, Verloes A (1999) : Hydrometrocolpos and polydactyly : a common neonatal presentation of Bardet-Biedl and McKusick-Kaufman syndromes. J Med Genet 36 : 599-603.
Del Campo M, Hall BD, Aeby A, Nassogne MC, Verloes A, Roche C, Gonzalez C, Sanchez H, Garcia-Alix A, Cabanas F, Escudero RM, Hernandez R, Quero J (1999) Albinism and agenesis of the corpus callosum with profound developmental delay: Vici syndrome. Evidence for autosomal recessive inheritance. Am J Med Genet 85: 479-485.
Massin M, Verloes A (1999) : Collatérales aortopulmonaires chez l'enfant porteur de la monosomie 22q11. Ann Cardiol Angéiol 48 : 199-203.
Massin MM, Radermecker MA, Verloes A, Jacquot S, Grenade T (1999) : Cardiac involvement in Coffin-Lowry syndrome. Acta Paediatr 88: 468-470.
Massin M, Verloes A, Jamblin P (1999) Cardiac anomalies associated with congenital absence of the portal vein. Cardiol Young 9 : 522-525.
Poncin J, Abs R, Velkeniers B, Bonduelle M, Abramowicz M, Legros JJ, Verloes A, Meurisse M, Van Gaal L, Verellen C, Koulischer L, Beckers A (1999) : Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases Hum Mut 13: 54-60.
Wang X, Tromp G, Cole W, Sakalihasan N, Verloes A, Yoon S, Kuivaniemi H (1999) Analysis of coding sequences for tissue inhibitor of metalloproteinase 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms. Matrix Biol 18: 121-124.
Nationalité : belge
Epouse Aïcha AGUELMIN, infirmière
Enfants : Alia (28.11.89), Arnaud (27.11.92), Alice (03.09.98)
Adresse : 13 Chaussée de Liège
4160 ANTHISNES
Tel 04-383. 66. 99
B. ETUDES MEDICALES
Médecine: diplome de docteur en Médecine , Chirurgie et Accouchements (1982), Université Libre de Bruxelles, mention: "Avec la plus grande distinction"
Pédiatrie: Formation à l'Université de l'Etat à Liège (Professeur F. Geubelle)
Reconnaissance INAMI de spécialiste en Pédiatrie en Janvier 1989, sous le numéro 1/64684/22/690. Reconnaissance de la compétence spéciale en néonatologie en 1997.
C. FORMATION EN GENETIQUE
Stage à la Clinique de Génétique Médicale de l'Hôpital des Enfants-Malades, Paris (service du Professeur Jean Frézal) du 1-X-1986 au 30-IX-1987.
Certificat d'Enseignement Spécialisé de Génétique Humaine Générale de l'Université René Descartes - Paris 5 - mention "bien" (1987).
Diplôme Universitaire de Foetopathologie - Université Pierre et Marie Curie - Paris 6 (1990). (Mémoire: «La dermopathie restrictive. A propos de deux observations.» défendu le 12 Octobre 1990)
D. CURSUS ACADEMIQUE
1) Grades académiques
Agrégé de l'Enseignement Supérieur (1997). Titre de la thèse: «Apports de l'étude des syndromes rares ou exceptionnels en génétique humaine»
Professeur de Clinique depuis 1er Janvier 1998
2) Enseignement universitaire
"Malformations congénitales, maladies génétiques et erreurs du métabolisme" (10 h). Cours créé en 1996
«Epidémiologie génétique». 2me licence en Santé Publique (15 heures) Cours créé en 1998
3) Membre Conseil Supérieur de Génétique (Ministère National de la Santé Publique et de l'Environnement) (nomination: A. R. du 14/09/92).
E. ACTIVITES HOSPITALIERES
Rang et affiliation actuels: chef de Clinique, service de Génétique du CHU de Liège
Fonctions
1) Responsable des consultations de Génétique Clinique dépendant du Centre de Génétique de Liège. Ces consultations couvrent tous les domaines de la Génétique Médicale (génétique «assique» de l'adulte et de l'enfant, diagnostic prénatal, diagnostic présymptomatique, oncogénétique). Elles sont assurées au CHU du Sart Tilman, au CHR de la Citadelle, et sur 12 sites hospitaliers périphériques, situés dans les provinces de Liège, de Luxembourg et du Hainaut. Ce réseau de consultation a été créé à mon instigation. Au total, ces consultations me permettent de voir approximativement 900 nouvelles familles par an, et de revoir environ 450 patients/familles en follow up.
2) Directeur du Centre Universitaire Wallon de Génétique Maladies métaboliques: reconnaissance INAMI en Janvier 1999
3) Superviseur du laboratoire de biochimie génétique et du centre de dépistage par tests multiples (dépistage néonatal sur sang sèché et Triple Test)
4) Superviseur des autopsies foetales et néonatales, en collaboration avec le service d'anatomopathologie du CHU.
F. ACTIVITE DE RECHERCHE
Mes travaux de recherche sont essentiellement cliniques. Ils concernent:
· la syndromologie des associations polymalformatives (avec ou sans dysmorphies)
· l'arriération mentale d'origine génétique.
Ces travaux portent sur la définition, la classification, la nosologie et/ou le déterminisme génétique (ou cytogénétique) d'affections exceptionnelles.Ils m'ont permis de décrire plusieurs "nouveaux" syndromes. Plusieurs articles résultent de collaborations nationales interuniversitaires, ou de collaborations internationales avec des collègues Français, Suisses, Britanniques et Américains. Ils ont débouché sur de nombreuses publications et forment notemment le substrat de ma thèse d'agrégation.
La reconnaissance de la qualité de ces travaux par la communauté des dysmorphologistes m'a permis
1) d'être un membre régulier des réunions de Dysmorphologies «rmées» (sur invitation) anglosaxonnes:
· Manchester Dysmorphology Meeting (Manchester, Grande-Bretagne)
· David Smith Workshop on Malformation and Morphogenesis (USA)
2) d'être membre du Comité de lecture de Clinical Dysmorphology et du comité scientifique d'ORPHANET (INSERM SC11), section dysmorphologie.
3) d'agir en tant que reviewer régulier pour les journaux suivants: J Med Genet, Am J Med Genet, Clinical Dysmorphology, Clin Genet, Genet Counsel, European Journal of Human Genetics.
G. BIBLIOGRAPHIE
La liste complète comporte actuellement 122 articles publiés dans des revues internationales avec comité de lecture, dont 65 environ comme premier auteur. Le facteur d'impact cumulé de ces 122 publications est de 227, sur base des FI de 1997. La liste des publications entre 1989 et 1999 figure dans un fichier texte ci-annexé.
Liste des articles 1989-1999
Verloes A, Le Merrer M, Briard ML (1989). BBBG syndrome or Opitz syndrome : new family. Am J Med Genet 32:313-316. Verloes A, Lambotte C (1989). Further delineation of a syndrome of Coloboma, Oligophrenia, Ataxia, Cerebellar vermis hypo/aplasia and Hepatic fibrosis. Am J Med Genet 32:237-242.
Verloes A, Delfortrie J, Lambotte C (1989). The GOMBO syndrome of Growth retardation, Ocular abnormalities, Microcephaly, Brachydactyly, and Oligophrenia. Am J Med Genet 32:15-18.
Verloes A, Dresse MF, Jovanovic M, Geubelle F (1989). 3C syndrome. Third Occurrence of Cranio-Cerebello-Cardiac Dysplasia (Ritscher-Schinzel syndrome). Clin Genet 35:205-208.
Verloes A, Herens C, Retz MC, Van Maldergem L, Dodinval P (1989). Exencephaly in Roberts-SC phocomelia. Ann Génet 32:169-170.
Herens C, Pierquin G, Verloes A, Schaaps JP, Frederic J (1989). Mosaicism of 46,XX/47,XX,+9/47,XX,+?mar in the same amniotic fluid with apparent loss of one cell line after delivery. Prenat Diag 9:373-375.
Rigo J, Verloes A, Senterre J (1989). Plasma aminoacid concentration in term infants fed human milk, a whey predominant formula, or a whey hydrolysate formula. J Pediatr 115:752-755.
Verloes A, Soyeur-Broux M, Arrese-Estrada J, Piérard-Franchimont C, Piérard G. (1990). Poikiloderma, alopecia, retrognathism and cleft palate: the PARC syndrome. Dermatologica 181:142-144.
Verloes A, Frikiche A, Paquay T, Gremillet C, De Cortis T, Rigo T, Senterre J (1990). Proximal phocomelia and radial ray aplasia after prenatal exposure to valproic acid. A case report. European J Pediatr 149:266-267.
Verloes A, Emonts P, Dubois JP, Senterre J (1990). Paraplegia and arthrogryposis after prenatal exposure to ergotamine. J Med Genet 27:213-214.
Verloes A, Dodinval P (1990). Rieger anomaly and uveal coloboma with associated anomalies. Third observation of a rare oculo-palato-osseous syndrome -the Abruzzo-Erikson syndrome. Ophthalm Paediatr Genet 11:41-47.
Verloes A, Dodinval P, Beco J, Lambotte C (1990). Lambotte syndrome : A new recessively inherited MCA/MR syndrome with severe brain malformations. Am J Med Genet 37:119-123.
Verloes A, Dodinval P, Bonnivert J, Lambotte R (1990). Etretinate embryotoxicity 7 months after discontinuing treatment. Am J Med Genet 37:119-123.
Verloes A, Van Maldergem L, de Marneffe P, Dufier J, Maroteaux P (1990). Microspherophakia-metaphyseal dysplasia. A "new" dominantly inherited bone dysplasia with severe eye involvement. J Med Genet 27:467-471.
Verloes A, Pierard GE, Le Merrer M, Maroteaux P (1990). Recessive metaphyseal dysplasia without hair involvement. J Med Genet 27:693-696.
Herens C, Verloes A, Laloux F, Van Maldergem L, Koulischer L (1990). Trisomy 20q. A new case and further phenotypic delineation. Clin Genet 37:363-366.
Piérard GE, Soyeur-Broux M, Arrese Estrada J, Piérard-FranchimontC, Soyeur D, Verloes A (1990). Cutaneous presentation of the cardio-facio-renal syndrome. J Am Acad Dermatol 22:920-922.
Ramaekers PR, Legius E, Verloes A, Gillerot Y, Vandenberghe K, Fryns JP (1990). Holoprosencephaly and postaxial polydactyly with normal chromosomes. Another observation of a new malformation syndrome. Eur J Obstet Gynecol Repr Biol 36:161-165.
Van Maldergem L, Gillerot Y, Salmin E, Verloes A, Koulischer L (1990). Lethal short rib with median cleft and without polydactyly: a fourth case. Pediatr Radiol 20:367-368.
Verloes A, Gillerot Y, Delfortrie J, Zeevaert-Arnold MT, Collard R, Koulischer L, Fryns JP (1991). Male pseudohermaphroditism with persistent Müllerian structures, mental retardation and Borjeson-Forssman-Lehmann - like features : a new syndrome? Genet Counsel, 38, 210-217.
Verloes A, Schaaps JP, Soyeur D, Hustin J, Herens C, Koulischer L (1991) Chorioangioma and hygroma colli revealing Wolf-Hirschhorn syndrome. Prenat Diag 11:129-132.
Verloes A, Dodinval P, Retz MC, Schaaps JP, Koulischer L (1991). A hydropic fetus with translucent ribs, arthrogryposis multiplex congenita and congenital myopathy : etiological heterogeneity of A. M. C. , Toriello-Bauserman type. Genet Counsel 2:63-66.
Verloes A, Le Merrer M, Farriaux JP, Maroteaux P (1991). Metaphyseal acroscyphodysplasia. Clin Genet 39:362-369.
Verloes A, Aymé S, Gambarelli D, Gonzales M, Le Merrer M, Mulliez N, Philip N, Roume J (1991). Holoprocencephaly and polydactyly ("pseudo-trisomy 13") syndrome: a syndrome with features of hydrolethalus and Smith-Lemli-Opitz syndromes. A collaborative multicentre study. J Med Genet 28:297-303.
Verloes A, Massart B, Jossa V, Langhendries JP, Hainaut H, Paquot JP, Koulischer L (1991). Neuroblastoma in a dwarfed newborn. Possible clue to the chromosomal localization of the gene for achondroplasia ?. Ann Génet, 34:25-26.
Verloes A, Seret N, Bernier V, Gonzales M, Herens C, Koulischer L (1991). Branchial arch anomalies in trisomy 18. Ann Génet 34:22-24.
Ben Mosbah T, Piérard-Franchimont C, Verloes A, Goffin F, Lesuisse M, Dodinval P, Piérard GE (1991). Le syndrome de Protée et ses altérations conjonctives cutanées. Giornale Internationale de Dermatologia Pediatrica 3;83-88.
Gibson KM, Sherwood WG, Hoffmann GF, Stumpf DA, Dianzani I, Schutgens RBH, Barth PG, Weismann U, Bachmann C, Schynemackers-Pitance P, Verloes A, Narisawa K, Mino M, Ohya N, Kelley RI (1991). Phenotypic heterogeneneity in the syndromes of 3-methylglutaconic aciduria. J Pediatr 118:885-890.
Maroteaux P, Verloes A, Stanescu V, Stanescu R (1991). Metaphyseal anadysplasia: a metaphyseal dysplasia of early onset with radiological regression and benign course. Am J Med Genet 39:4-10.
Schoos R, Dodinval-Versie J, Verloes A, Lambotte C, Koulischer L (1991). Alpha-1-antitrypsin neonatal screening on dried blood by ELISA. Report of 39289 newborns. Clin Chem 37:821-825.
Van Maldergem L, Avni F, Mossay B, Herens C, Verloes A, Gillerot Y (1991). Ring chromosome 9 in a newborn male presenting with facial dysmorphia, hypospadias and skeletal abnormalities. Genet Counsel 2;123-127.
Van Maldergem L, Espeel M, Roels F, Petit C, Dacremont G, Wanders RJA, Verloes A, Gillerot Y (1991). X-linked recessive chondrodysplasia punctata with XY translocation in a stillborn fetus. Hum Genet 87:661-664.
Verloes A, Gillerot Y, Walczak E, Van Maldergem L, Koulischer L (1992). Acromelic frontonasal "Dysplasia". Further delineation of a subtype with brain malformation and polydactyly (Toriello syndrome). Am J Med Genet 42:180-183.
Verloes A, Le Merrer M, Davin JC, Wittamer P, Abrassart C, Bricteux G, Briard ML (1992). The orocraniodigital syndrome of Juberg and Hayward. J Med Genet 29:262-265 .
Verloes A, Mulliez N, Gonzales M, Laloux F, Hermanns-Lê T, Piérard GE, Koulischer L (1992). Restrictive dermopathy. A lethal form of arthrogryposis multiplex with skin and bone dysplasias : three new cases and review of the literature. Am J Med Genet 43:539-547.
Verloes A, Le Merrer M (1992). Lumping of CFC and Baraitser-Patton Noonan-like syndrome. Am J Med Genet 42:756.
Verloes A, Gillerot Y, Langhendries JP, Fryns JP, Koulischer L (1992). Variability versus Heterogeneity in syndromal Hypothalamic Hamartoblastoma and related disorders. Review and Delineation of the Cerebro-Acro-Visceral-Early lethality (CAVE) multiplex Syndrome. Am J Med Genet 43:669-677.
Verloes A, Schoos R, Koulischer L (1992). Non-radioactive assay od AFP, HCG and uE3 on dried blood specimen : a low cost alternative for the maternal screening for Trisomy 21. Prenat Diag 12:1073-1074. .
Verloes A, Hermia JP, Galand A, Koulischer L, Dodinval P (1992). Glaucoma-lens Ectopia-Microspherophakia-Stiffness-Shortness (GEMSS) syndrome. A dominant syndrome with features of Weill-Marchesani and Moore-Federman syndrome. Am J Med Genet 44:48-51.
Verloes A, Koulischer L (1992). New oral-acral syndrome with partial agenesis of the maxillary bones. Am J Med Genet 44:605-607.
Lapière JC, Verloes A, Herens C, Delfortrie J, Van Maldergem L, Gillerot Y, Koulischer L (1992). Combined 10pter-p11 and 18pter-q11 trisomy in a 7-year-old child. Genet Counsel 3,155-159
Piérard-Franchimont C, Piérard GE, Hermanns-Lê T, Arrese Estrada J, Verloes A, Mulliez N (1992). Dermatopathological aspects of restrictive dermopathy. Am J Surg Pathol 166:223-228.
Scalais E, Verloes A, Sacré JP, Piérard GE, Rizzo WB (1992). Sjögren-Larsson-like syndrome with bone dysplasia and normal fatty alcohol NAD+ oxydoreductase activity. Pediatric Neurology 8:459-465.
Van Maldergem L, Wetzburger C, Verloes A, Fourneau C, Gillerot Y (1992). Mental retardation with blepharonasofacial abnormalities and hand malformations : a new syndrome ? Clin Genet 41:22-24.
Van Maldergem L, Verloes A, Lejeune L, Gillerot Y (1992). The Baller-Gerold syndrome. J Med Genet 29:266-268.
Verloes A, Elmer C, Lacombe D, Heinrichs C, Rebuffat E, Demarquez JL, Moncla A, Adam E (1993). Ondine-Hirschsprung syndrome (Haddad syndrome). Further delineation in two cases and review of the literature. Eur J Pediatr 152:75-77.
Verloes A, Bonneau D, Guidi O, Berthier M, Oriot D, Van Maldergem L, Koulischer L (1993). Brachymorphism-Onychodysplasia-Dysphalangy syndrome. J Med Genet 30:158-161.
Verloes A, Moës D, Palumbo G, Elmer C, François A, Bricteux G (1993). Schinzel-Giedion syndrome. Eur J Pediatr 152:421-423.
Verloes A, Journel H, Elmer C, Misson JP, Le Merrer M, Kaplan J, Van Maldergem L, Deconinck H, Meire F, (1993). Heterogeneity versus variability in megalocornea-mental retardation (MMR) syndromes. Report of new cases and delineation of 4 probable types. Am J Med Genet 46:132-137.
Verloes A (1993). Iris coloboma, ptosis, hypertelorism and mental retardation : Baraitser-Winter syndrome or Noonan syndrome ? . J Med Genet 30:425-426.
Verloes A, Bricteux G, Koulischer L. (1993). Pseudo-aminopterin syndrome. Am J Med Genet 46:394-397.
Hustinx R, Verloes A, Grattagliano B, Herens C, Jamar M, Soyeur D, Schaaps JP, Koulischer L (1993). Monosomy 11q. Report of two familial cases and review of the literature. Am J Med Genet 47:312-317.
Lacombe D, Bonneau D, Verloes A, Couet D, Koulischer L, Battin J (1993). Lujan-Fryns syndrome (X-linked mental retardation with Marfanoid habitus) : report of three cases and review. Genet Counsel 4: 193-198.
Verloes A, Ernould C, Dubru JM, Malchair R, Koulischer L (1994). Diabetes mellitus, mental retardation, lipodystrophy and dysmorphic traits. Clin Dysmorphol 3: 160-163.
Verloes A (1994). Severe acrocallosal syndrome or acromelic frontonasal dysplasia ? Am J Med Genet 49, 306.
Verloes A, Narcy F, Grattagliano B, Delezoide A, Guibaud P, Schaaps JP, Le Merrer M, Maroteaux P (1994) Osteocraniostenosis. J Med Genet 31: 772-778
Verloes A (1994). Hypertelorism-microtia-clefting syndrome. Genet Counsel 5: 283-287
Edery P, Pelet A, Mulligan LM, Abel L, Attié T, Dow E, Bonneau D, David A, Flintoff W, Jan D, Journel H, Lacombe D, LeMerrer M, Meijers C, Parent P, Philip N, Plauchu H, Sarda P, Verloes A, Nihoul-Fékété C, Williamson R, Ponder BAJ, Munnich A, Lyonnet S (1994) Long segment and short segment familial Hirschsprung's disease : variable clinical expression at the RET locus. J Med Genet 31:602-606.
Schrander-Stumpel C, Meinecke P, Wilson G, Gillessen-Kaesbach G, Tinschert S, König R, Phillip N, Rizzo R, Schrander J, Pfeiffer L, Maat-Kievit A, van der Burgt I, van Essen T, Latta E, Hillig U, Verloes A, Journel H, Fryns JP (1994). The Kabuki (Niikawa-Kuroki) syndrome : further delineation of the phenotype in 27 non-japanese patients. Eur J Pediatr 153:438-445.
Verloes A, Narcy F, Fallet-Bianco C (1995). Syndromal hypothalamic hamartoblastoma with holoprosencephaly sequence, microphthalmia, pulmonary malformations, radial hypoplasia and Müllerian regression. Further delineation of new syndrome ? Clin Dysmorphol 4:33-37.
Verloes A, David A (1995). Dominant mesomelic shortness of stature with acral synostoses, umbilical anomalies, and soft palate agenesis. Am J Med Genet 55. 205-212
Verloes A (1995). Numerical syndromology. A mathematical approach to the nosology of complex phenotypes. Am J Med Genet 55. 433-443
Verloes A, Schoos R, Herens C, Vintens A, Koulischer L (1995). A prenatal Trisomy 21 screening program using AFP, hCG and uE3 on dried blood. Am J Obstet Gynaecol 172: 167-174.
Verloes A, Sakalihasan N, Limet R, Koulischer L (1995). Aneurysms of the abdominal aorta. A familial and genetic study in three hundred thirteen pedigrees. J Vasc Surg 21, 646-655.
Verloes A, Massart B, Dehalleux I, Langhendries JP, Koulischer L (1995). Diagnostic pittfall : a child overlapping Beckwith-Wiedemann, Perlman, Denys-Drash and Simpson-Golabi-Behmel syndromes. Clin Genet 47:257-262. .
Verloes A, Misson JP, Dubru JM, Jamblin P, LeMerrer M (1995). Heterogeneity of SPONASTRIME dysplasia: delineation of a variant form with mental retardation Clin Dysmorphol 4, 208-215
Verloes A, David A, Ngô L, Bottani A (1995). Stringent delineation of Pallister-Hall syndrome (stricto sensu) in 2 long-surviving patients: importance of radiological anomalies of the hands. J Med Genet 32, 605-611
Verloes A, David A, Odent S, Toutain A, André MJ, Lucas J, Le Marec B (1995). Opitz GBBB syndrome: chromosomal rvidence of an X-linked form. Am J Med Genet. Am J Med Genet 59, 123-128.
Bottani A, Verloes A (1995) The Myhre-GOMBO syndrome: possible lumping of two "old" new syndromes ? Am J Med Genet 59, 523-4.
Ectors FJ, Koulischer L, Jamar M, Herens C, Verloes A, Remy B, Beckers JF (1995). Cytogenetic study of bovine oocytes matured in vitro. Theriogenology 44:445-450.
Gilbert-Dussardier B, Bonneau D, Gigarel N, Le Merrer M, Bonnet D, Philip N, Serville F, Verloes A, Rossi A, Aymé S, Weissenbach J, Mattéi MG, Lyonnet S, Munnich A (1995) A novel microsatellite DNA marker at locus D7S1870 detects hemizygocity in 75 % of patients with Williams syndrome. Am J Hum Genet 56:542-543
Lacombe D, Pedespan JM, Fontan D, Chateil JF, Verloes A (1995). Phenotypic variability in Van Der Woude syndrome. Genet Counsel 6,221-226.
Verloes A, Jamblin P, Koulischer L, Bourguignon JP (1996). A new form of skeletal dysplasia with amelogenesis imperfecta and platyspondyly. Clin Genet 49, 2-5.
Verloes A, Temple IK, Hubert AF, Hope P, Gould S, Debauche C, Verellen G, Deville JL, Koulischer L, Sokal E (1996). Recurrence of neonatal hemochromatosis in half-sibs born from unaffected mothers. J Med Genet 33: 444-449
Verloes A, Lesenfants S, Philippet B, Iyawa A, Laloux F, Koulischer L (1996). Microcephaly, macrotia, unusual mimics and mental retardation new syndrome or variant of de Lange type 2 syndrome. Genet Counsel 7: 277-282.
Verloes A, Sakalihasan N, Limet R, Koulischer L (1996). Genetic aspects of abdominal aortic aneurysm. Ann NY Acad Sci 800, 44-55
Biesecker LG, Abbott M, Allen J, Clericuzio C, Feuillan P, Graham J Jr, Hall J, Kang S, Haskins Olney A, Lefton D, Neri G, Peters K, Verloes A (1996). Report of the workshop on Pallister-Hall and related phenotypes. Am J Med Genet 65:76-81.
Bürglen L, Amiel J, Viollet L, Lefebvre S, Burlet P, Clermont O, Raclin V, Landrieu P, Verloes A, Munnich A, Melki J (1996). SMN gene deletion in the arthrogryposis multiplex congenita-spinal muscular atrophy association. J Clin Invest 98:1130-1132
David A, Mercier J, Verloes A (1996). Child with manifestations of Nager acrofacial dysostosis, and the MURCS, VACTERL, and pulmonary agenesis associations : complex defect of blastogenesis? Am J Med Genet 61, 1-5.
David A, Nombalais MF, Rival JM, Verloes A (1996). Nosology of fetal hypokinesia sequence based on CNS abnormalities: is there an Aase-Smith syndrome? Clin Genet 50, 251-254
Narbay G, Meire F, Verloes A, Casteels I, Devos E (1996). Ocular manifestations in Delleman syndrome (oculocerebrocutaneous syndrome, OCC-syndrome) and encephalocraniocutaneous lipomatosis (ECCL) - report of three cases. Bull Soc Belg Ophtalmol 261:65-70.
Verloes A, Lesenfants S (1997). A new form of mandibulofacial dysostosis with macroblepharon and macrostomia. Clin Dysmorphol 6:21-24.
Verloes A (1997). Osteocraniostenosis vs. Hallermann-Streiff-François syndrome. Am J Med Genet 64:105-107.
Verloes A, Lombet J, Lambert Y, Hubert AF, Deprez M, Fridman V, Gosseye S, Rigo J, Sokal E (1997). Tricho-hepato-enteric syndrome: further delineation of a distinct form of neonatal hemochromatosis with intractable diarrhoea, and hair anomalies. Am J Med Genet 68:391-395.
Verloes A, Lesenfants S, Misson JP, Galand A, Koulischer L (1997). Microcephaly, muscular build, rhizomelia and cataracts: a possible recessive syndrome, and some comments on the use of electronic databases in syndromology. Am J Med Genet 68:455-460.
Verloes A, Temple IK, Bonnet S, Bottani A (1997). Coloboma, mental retardation, hypogonadism and obesity: critical review and updated nosology of the so called «Biemond syndrome type 2», updated nosology, and delineation of three «w» syndromes. . Am J Med Genet 69:370-379.
Verloes A, Massin M, Lombet J, Grattagliano B, Soyeur D, Rigo J, Koulischer L, Van Hoof F (1997): Nosology of lysosomal glycogen storage diseases without in vitro acid maltase deficiency: delineation of a neonatal form. Am J Med Genet 72: 135-142.
Verloes A, Maquet P, Sadzot B, Vivario M, Thiry A, Franck G Nasu-Hakola syndrome (1997) : polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy. J Med Genet 34:753-757.
Courtens W, Levi S, Verbelen F, Verloes A, Vamos E (1997) : Feingold syndrome : report of a new family and review. Am J Med Genet 60:55-60.
Gladwin A, Donnai D, Metcalfe K, Schrander-Stumpel C, Brueton L, Verloes A, Aylsworth A, Toriello H, Winter R, Dixon M (1997). Localization of a gene for oculodentodigital syndrome to human chromosome 6q22-q24. Hum Mol Genet 6:123-127.
Herens C, Jamar M, Alvarez-Gonzalez ML, Lesenfants S, Lombet J, Bonnivert J, Koulischer L, Verloes A (1997). Private multiple congenital anomaly syndromes may result from unbalanced subtle translocations: t(2q;4p) explains the Lambotte syndrome.Am J Med Genet 73:127-131
Koulischer L, Verloes A, Lesenfants S, Jamar M, Herens C (1997) : Genetic risk in natural and medically assisted procreation. Early Pregn Biol Med 3:164-171.
Verloes A, Curry C, Jamar M, Herens C, O'Lague P, Marks J, Sarda P, Blanchet P (1998): Juvenile rheumatoid arthritis and del(22q11) syndrome: a non-random association. J Med Genet 35:943-947
de Silva D, Verloes A (1998): Further delineation of the Verloes-Koulischer-oro-acral syndrome. Am J Med Genet 80:535-537.
Gelb BD, Willner JP, Dunn TM, Kardon NB, Verloes A, Poncin J, Desnick RJ (1998) Paternal Uniparental Disomy for Chromosome 1 Revealed by Molecular Analysis of a Patient with Pycnodysostosis. Am J of Hum Genet 62:848-854
Leroy JG, Nuytinck L, De Paepe A, De Rammelaere M, Gillerot Y, Verloes A, Loeys B, De Groote W (1998): Bruck syndrome: neonatal presentation and natural course in three patients. Pediatr Radiol 28:781-789
Limet R, Nusgens B, Verloes A, Sakalihasan N (1998): Pathogenesis of abdominal aortic aneurysm (AAA) formation. Acta Chir Belg 98:195-198.
Odent S, Le Marec B, Toutain A, David A, Vigneron J, Tréguier C, Jouan H, Milon J, Fryns JP, Verloes A (1998). Central nervous system malformations and early end-stage renal disease in oro-facio-digital syndrome type I: a review. Am J Med Genet 75:389-394.
Plomp AS, Hamel BC, Cobben JM, Verloes A, Offermans JP, Lajeunie E, Fryns JP, de Die-Smulders CE (1998). Pfeiffer syndrome type 2: further delineation and review of the literature. Am J Med Genet 75:245-251.
Van Coster RN, Janssens S, Misson JP, Verloes A, Leroy JG (1998): Prenatal diagnosis of pyruvate carboxylase deficiency by direct measurement of catalytic activity on chorionic villi samples. Prenat Diagn 18:1041-1044.
Verloes A, Stevenaert A, Teh BT, Petrossians P, Beckers A (1999) : Familial acromegaly : case report and review of the literature. Pituitary 1 : 273-277.
Verloes A, Hermanns-Lê T, Lesenfants S, Lombet J, Lamotte PJ, Crèvecoeur-Liégeois C, Duchesne B, Piérard GE (1999) : Koraxitrachitic Syndrome : a syndromic form of self-healing collodion baby with residual dappled atrophy of the derma. Am J Med Genet 86 : 454-458.
David A, Bitoun P, Lacombe D, Lambert JC, Nivelon A, Vigneron J, Verloes A (1999) : Hydrometrocolpos and polydactyly : a common neonatal presentation of Bardet-Biedl and McKusick-Kaufman syndromes. J Med Genet 36 : 599-603.
Del Campo M, Hall BD, Aeby A, Nassogne MC, Verloes A, Roche C, Gonzalez C, Sanchez H, Garcia-Alix A, Cabanas F, Escudero RM, Hernandez R, Quero J (1999) Albinism and agenesis of the corpus callosum with profound developmental delay: Vici syndrome. Evidence for autosomal recessive inheritance. Am J Med Genet 85: 479-485.
Massin M, Verloes A (1999) : Collatérales aortopulmonaires chez l'enfant porteur de la monosomie 22q11. Ann Cardiol Angéiol 48 : 199-203.
Massin MM, Radermecker MA, Verloes A, Jacquot S, Grenade T (1999) : Cardiac involvement in Coffin-Lowry syndrome. Acta Paediatr 88: 468-470.
Massin M, Verloes A, Jamblin P (1999) Cardiac anomalies associated with congenital absence of the portal vein. Cardiol Young 9 : 522-525.
Poncin J, Abs R, Velkeniers B, Bonduelle M, Abramowicz M, Legros JJ, Verloes A, Meurisse M, Van Gaal L, Verellen C, Koulischer L, Beckers A (1999) : Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases Hum Mut 13: 54-60.
Wang X, Tromp G, Cole W, Sakalihasan N, Verloes A, Yoon S, Kuivaniemi H (1999) Analysis of coding sequences for tissue inhibitor of metalloproteinase 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms. Matrix Biol 18: 121-124.
©2001 Ph. Evrard
